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18176

Adrenal Suppression Induced by Megestrol Acetate and the possible protective role of selenium A Histological , Histochemical and Ultrastructural Study

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Last updated: 03 Jan 2025

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Abstract

The anticancer drug megestrol acetate (MA) is suspected to cause adrenal insufficiency. Several clinical reports indicated that suppressed adrenal function might be possible in long term administration of MA . The present study was designed to evaluate this issue by using the histological, histochemical and ultrastructural techniques. The data obtained from the present study indicated that MA caused various cellular and subcellular damages in most of the cells of the three zones of adrenal cortex. Histochemical investigations indicated increased lipid content associated with increased storage of ascorbic acid and acid phosphatase, and all these data might reflect a state of suppressed steroidogenesis. The results also indicated that selenium might have a protective role against the cytotoxicity of megestrol acetate on adrenocortical cells. All the results were discussed and it is concluded that more followup of adrenal function should be done during the long term treatment with MA, and an additional protective supplement .

DOI

10.21608/ejhm.2004.18176

Authors

First Name

Hamdy Hamed

Last Name

Swelim

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Ain Shams University

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Orcid

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Volume

16

Article Issue

1

Related Issue

3781

Issue Date

2004-07-01

Receive Date

2018-11-01

Publish Date

2004-07-01

Page Start

65

Page End

91

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 16_Issue 1_Pages 65-91.pdf

PDF . 1.3MB

Link

https://ejhm.journals.ekb.eg/article_18176.html

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https://ejhm.journals.ekb.eg/service?article_code=18176

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6

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Adrenal Suppression Induced by Megestrol Acetate and the possible protective role of selenium A Histological , Histochemical and Ultrastructural Study

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Article

Created At

22 Jan 2023