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18175

Antihepatotoxic potential of ginseng (Panax ginseng) in thioacetamide-induced acute hepatocellular injury in rats

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Last updated: 30 Jan 2023

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Abstract

Previous studies demonstrated the hepatotoxicity of thioacetamide (TAA) in rats. The present study is a trial to decline TAA-hepatotoxicity by using the roots of herbal medicinal plant (Panax ginseng) pre-treatment . Low dose of TAA (50-mg/kg b.wt) was chosen to induce hepatoxicity in male rats previously treated with ginseng for 10 consecutive days. The tested parameters were studied after 24, 48 and 72 hours post TAA intoxication. Fluctuatious of serum glucose were noticed in TAA intoxicated rats increased after 24 h (+ 9.31%), 48h. (+ 7.11%), followed by moderate improvement after 72 h. (+5.39%) when compared with control group. Ginseng pretreatment enhanced these changes towards the normal values. Serum and liver enzyme activities ( AST, AIT, ALP and GT) increased in TAA intoxicated rats which peaked after 48 h, and began to decrease after 72h. Pretreatment with ginseng improved enzyme activities to some extent. Reduced glutathione (GSH) as well as antioxidant enzyme glutathione reductase (GSH-R) activity while lipid peroxidation (LPO) increased in TAA intoxicated rats and enhanced by pretreatment with ginseng. This results suggest that pretreatment with ginseng could improve the detoxifying activity of the liver rats with TAA-induced acute hepatotoxicity.  

DOI

10.21608/ejhm.2004.18175

Keywords

Liver toxicity- Thioacetamide- Ginseng, Liver Function - Liver antioxidant - Lipid peroxidation

Authors

First Name

Amira Tohamey

Last Name

Ebrahim

MiddleName

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Affiliation

Faculty of Science (Girls) Al-Azhar University, Egypt

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Orcid

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First Name

Ahkam, M.

Last Name

El-Gendy

MiddleName

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Affiliation

Faculty of Science (Girls) Al-Azhar University, Egypt

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Orcid

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First Name

Boshra

Last Name

El-Zawahry

MiddleName

-

Affiliation

Faculty of Medicine (Girls) Al-Azhar University, Egypt

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Volume

16

Article Issue

1

Related Issue

3781

Issue Date

2004-07-01

Receive Date

2018-11-01

Publish Date

2004-07-01

Page Start

55

Page End

64

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 16_Issue 1_Pages 55-64.pdf

PDF . 285.5kB

Link

https://ejhm.journals.ekb.eg/article_18175.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18175

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023