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18167

Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients

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Last updated: 03 Jan 2025

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Abstract

It has been noticed that there is an increase in the number of women suffering from SLE. Most studies confirmed that serum DHEA (dehydroepiandrosterone) and DHEA sulphate are lower among patients with SLE than among controls even- during phases of inactive disease so we performed this study to detect the level of DHEA-S in the female patients with SLE. The overall results confirm that DHEA treatment was well- tolerated, significantly reduced the number of SLE flares, and improved patient's global assessment of disease activity. Some serum parameters like liver and kidney functions were detected. Biochemical analysis showed that there is a significant increase of total lipids, cholestrol, triglycerides. But insignificant change in serum glucose, urea nitrogen and uric acid levels were recorded. From the present study three things were concluded. Firstly, there is a strong relationship between level of DHEA and the progression of SLE. Secondly, liver activity and kidney functions were not affected by SLE disease.Thirdly, DHEA treatment has a beneficial effect on female patients. So this study recommended to follow up DHEAS in female patients and use it in a proper dosage. In addition, further study must be done.  

DOI

10.21608/ejhm.2004.18167

Keywords

SLE, DHEA, Liver functions, kidney functions

Authors

First Name

Eman G.E

Last Name

Helal

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Al- Azhar University (Girls)

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Orcid

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First Name

Medhat

Last Name

El- Shafaey

MiddleName

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Affiliation

Clinical Immunology and Allergy Department, Faculty of Medicine, Ain- Shams University.

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City

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Orcid

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First Name

Hala

Last Name

Rahoma

MiddleName

-

Affiliation

Clinical Immunology and Allergy Department, Faculty of Medicine, Ain- Shams University.

Email

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City

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Orcid

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First Name

Mervat

Last Name

Abdel- Rahman

MiddleName

-

Affiliation

Clinical Pathology Lab., Student Hospital, Cairo University.

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

187

Page End

196

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 187-196.pdf

PDF . 373.3kB

Link

https://ejhm.journals.ekb.eg/article_18167.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18167

Order

15

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Systemic Lupus Erythematosus on some Biochemical Parameters in Female Patients

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Article

Created At

22 Jan 2023