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Mutagenic studies on the effect of Aldicarb “Temik” and vitamin C as antioxidant agent on the white rat: (Chromosomal aberrations and Micronucleus tests)

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Last updated: 03 Jan 2025

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Abstract

Widespread contamination of the environment due to increased and frequently indiscriminate usage of insecticides during the last two decades has aroused much concern over the possibility of their radiominetic effect. Evidence accumulating over the years emphasized the indisputable link between certain insecticides, chromosomal damage and possibility of gene mutation. There is a wide variety of insecticides, among which the carbamates. Their chemical relationship to ethyl carbamate makes them worthy of study for their possible deleterious effect on biological system. The main object of the present study is to evaluate the mutagenic effect of a carbamate insecticide" Aldicarb" alone and in combination of vitamin C as an antioxidant agent to decrease their mutagenicity. Male albino rats were tested orally for 48 hours , two doses of aldicarb were used in absence and in the presence of viamin C (1/4 and 1/10) LD50. The obtained data showed highly significant increase in the micronucleus (PCEM) and in chromosomal aberrations in rat bone marrow cells at the two doses of aldicarb compared to control group. (P< 0.0001). The frequency of chromosomal aberrations and micronucleus decreased in rats treated with aldicarb and vitamin C than in aldicarb treated group. From these results we concluded that cytogenetic effect of aldicarb might be decreased by the usage of vitamin as an antioxidant agent.  

DOI

10.21608/ejhm.2004.18164

Keywords

Carbamate, Aldicarb, Chromosomal aberration, micronucleus, Antioxidant agents

Authors

First Name

Fatma M.

Last Name

Hamam

MiddleName

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Affiliation

Department Of Mammalian Toxicology, Central Agricultural Pesticides Laboratory

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Orcid

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First Name

Ihab H.

Last Name

Foda

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Affiliation

Agricultural Research Center, Ministry Of Agriculture

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

143

Page End

154

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 143-154.pdf

PDF . 631.8kB

Link

https://ejhm.journals.ekb.eg/article_18164.html

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https://ejhm.journals.ekb.eg/service?article_code=18164

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12

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Mutagenic studies on the effect of Aldicarb “Temik” and vitamin C as antioxidant agent on the white rat: (Chromosomal aberrations and Micronucleus tests)

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Article

Created At

22 Jan 2023