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18158

Cytogenetic and Developmental Effects of Antidepression Drug (Cipralex) on Female Mice and Embryos

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Last updated: 30 Jan 2023

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Abstract

Escitalopram (cipralex®) a new highly selective serotonin reuptake inhibitor, it is effective in the treatment of patients with major depression. To evaluate the cytogenetics and developmental effects of cipralex throughout major organgenesis, mice were administrated orally with a doses of 0.06, 0.12 and 0.24 mg/kg/day cipralex on gestation days 1-18 and examined on the 19th day of gestation for evidence of maternal and fetal toxicity. Cipralex at different doses tested produce significant toxic effects in reproductive parameters. Significant embryo fetotoxic effects were observed at tested dose levels as evidenced by total number of implantations, post. Implantation loss and embryo malformations. There were increases in the frequencies of micronuclei and chromosomal aberrations in both maternal and embryonic cells treated with cipalex, these increases were dose dependent. These results indicate that cipralex is considered to be cytogenetic and embryo toxic drug when administered during pregnancy.  

DOI

10.21608/ejhm.2004.18158

Keywords

Escitalopram, chromosomal aberrations – micronuclei – embryo – mice

Authors

First Name

Hanaa M.

Last Name

Roshdy

MiddleName

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Affiliation

Cell Biology Department, National Research Center Dokki, Cairo, Egypt

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First Name

Thanaa M.T

Last Name

Shoman

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Affiliation

Cell Biology Department, National Research Center Dokki, Cairo, Egypt

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

63

Page End

69

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 63-69.pdf

PDF . 287.5kB

Link

https://ejhm.journals.ekb.eg/article_18158.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18158

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023