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18157

Possible Association Between the Chemokine Receptor Gene CCR5- Delta32 Mutation and Hepatitis C Virus Pathogenesis

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Last updated: 03 Jan 2025

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Abstract

Background: CCR5-Delta32, a 32-base pair deletion of the CC chemokine receptor (CCR)5 gene, is associated with slowed human immunodeficiency virus disease progression in heterozygotes and protection against infection in homozygotes between carriers and non-carriers of each genetic variant. The present study investigated the frequency and clinical consequence of the CCR%-Delta32 mutation in Egyptian HCV infected patients. Genomic DNA samples from 150 patients with chronic HCV infection were screened by PCR for the presence of the CCR5-Delta32 polymorphism. One hundred blood donors were used as control population. Results: The frequency of CCR5-Delta32 heterozygosity was 0.67% in chronic hepatitis C virus and 0% in controls. The CCR5-Delta32 allele was not associated with any of the clinical parameters of hepatitis C virus infection.
Conclusion: In this study, the frequency of CCR5-Delta32 homozygosity in patients with hepatitis C was similar to controls.

DOI

10.21608/ejhm.2004.18157

Authors

First Name

Kouka Saad Eldin

Last Name

Abdel-Wahab

MiddleName

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Affiliation

Department of Medical Microbiology, Faculty of Medicine for Girls,

Email

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City

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Orcid

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First Name

Mohamed

Last Name

Foda

MiddleName

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Affiliation

Department of Medical Virology School of Medicine, Kumamoto University, Japan;

Email

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City

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Orcid

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First Name

Magda Abdel- Moneim

Last Name

Gamil

MiddleName

-

Affiliation

Department of Medical Microbiology, Faculty of Medicine for Girls

Email

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City

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Orcid

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First Name

Azza-Hassan

Last Name

El-salakawy

MiddleName

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Affiliation

Department of Medical Microbiology, Faculty of Medicine for Girls

Email

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City

-

Orcid

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First Name

Gamal

Last Name

El-Attar

MiddleName

-

Affiliation

Department of Internal Medicine, Theodore Bilharz Institute, Imbaba, Egypt

Email

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City

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Orcid

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First Name

Shinji

Last Name

Harada

MiddleName

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Affiliation

Department of Medical Virology School of Medicine, Kumamoto University, Japan

Email

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City

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Orcid

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First Name

Yosuke

Last Name

Maeda

MiddleName

-

Affiliation

Department of Medical Virology School of Medicine, Kumamoto University, Japan

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City

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Orcid

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

58

Page End

62

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 58-62.pdf

PDF . 318.7kB

Link

https://ejhm.journals.ekb.eg/article_18157.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18157

Order

5

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Possible Association Between the Chemokine Receptor Gene CCR5- Delta32 Mutation and Hepatitis C Virus Pathogenesis

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Article

Created At

22 Jan 2023