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18153

Reproductive and Developmental Effects of Moxifloxacin on Female Mice and Embryos

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Last updated: 03 Jan 2025

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Abstract

Moxifloxacin (Avelox®) is a fluoroquinolone antibiotic with a broad spectrum of activity and bactericidal action. Moxifloxacin has in vitro activity against a wide range of Gram- positive and Gram-negative organisms. The safe use of moxifloxacin in human pregnancy has not been established. In order to evaluate the genotoxic and embryo toxic effects of (Avelox)® during pregnancy, Avelox was administrated orally to female mice with doses (8.7, 17 and 26 mg/kg/day) from 1 to 17 days of pregnancy. Caesarean sections were completed on gestation day 18 and complete fetal examinations and cytogenetic analysis were conducted. Decreases in the fetal body weights and increases in the external visceral and skeletal anomalies were found in all doses of (8.7, 17 and 26 mg) Avelox compared to the controls. Cytogenetic analysis in mothers and embryos revealed that all the tests doses produced chromosomal aberrations and micronuclei (MN) formations in a dose dependent manner compared to the controls. These results indicate that Avelox has a maternal and embryotoxic effects on the female mice and their embryos when administered with a recommended and above the recommended dose during pregnancy.  

DOI

10.21608/ejhm.2004.18153

Keywords

Moxifloxacin, chromosomal aberrations – micronuclei – mice – embryos

Authors

First Name

Hanaa M.

Last Name

Roshdy

MiddleName

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Affiliation

Cell Biology Department, National Research Center Dokki, Cairo, Egypt

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Orcid

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

12

Page End

19

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 12-19.pdf

PDF . 268.7kB

Link

https://ejhm.journals.ekb.eg/article_18153.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18153

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Reproductive and Developmental Effects of Moxifloxacin on Female Mice and Embryos

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Article

Created At

22 Jan 2023