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18152

Mitochondria and Nuclear changes in postimplanted mice embryos After treatment with Cisplatim antitumour drugs

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Last updated: 03 Jan 2025

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Abstract

To evaluate a possible relationship of maternal exposure to capsulation during postimp- lantation embryotoxicity, SWR pregnant female mice were injected intraperitoneally on day 4 of gestation with 7mg/kg cisplatin or with saline (0.4 ml) for the control group. Embryos were collected after 24h 48h, 72h, after injection. ultrastructural sections were used to investigate the mitochondria and the nuclear changes Both the mitochondria and the nuclei were damaged specially 48h and 72 h after injection they may be related to cytotoxicity of the drug.

DOI

10.21608/ejhm.2004.18152

Keywords

platinum antitumour drugs, mitochondria, Nucleus, Mice embryos

Authors

First Name

Hassan M.

Last Name

El Ashmaoui

MiddleName

-

Affiliation

National Research center, Cell Biology Dept., Giza, Egypt

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Orcid

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Volume

17

Article Issue

1

Related Issue

3780

Issue Date

2004-10-01

Receive Date

2018-11-01

Publish Date

2004-10-01

Page Start

1

Page End

11

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 17_Issue 1_Pages 1-11.pdf

PDF . 635.3kB

Link

https://ejhm.journals.ekb.eg/article_18152.html

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https://ejhm.journals.ekb.eg/service?article_code=18152

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Mitochondria and Nuclear changes in postimplanted mice embryos After treatment with Cisplatim antitumour drugs

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Article

Created At

22 Jan 2023