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18055

Angiotensin Converting Enzyme Gene Polymorphism in Egyptian Patients with Systemic Lupus Erythematosus

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Last updated: 03 Jan 2025

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Abstract

Systemic lupus erythematosus (SLE) shows various clinical manifestations with various immunological abnormalities. The development of lupus nephritis and vasculitis is common in patients with SLE. As angiotensin I-converting enzyme (ACE) has been reported to be associated with various immunological phenomena, we investigated the correlation between insertion(I) / deletion(D) polymorphism of the ACE gene and SLE. Fifty Egyptian patients with SLE and thirty healthy control persons were involved in this study. ACE gene was detected by the polymerase chain reaction (PCR). In SLE patients, there is a significant difference when comparing DD and II genotypes (P<0.05),being higher in the DD genotype. And a highly significant difference when comparing ID and II genotypes (P=0.001), being much higher in ID genotype than II genotype. According to vasculitis, there is a significant relationship between vasculitis and patients genotypes when comparing ID genotype with both II and DD genotypes (P<0.05), being highest in ID genotype. There is a significant relationship found when comparing ID genotype with both II and DD genotypes, being highest in ID genotype in patients with score ≥21. These results suggest that the ACE genotype could be associated with SLE.

DOI

10.21608/ejhm.2005.18055

Authors

First Name

El-Shafeey

Last Name

M.M

MiddleName

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Affiliation

Allergy and Immunology Department of Internal Medicine in Ain Shams University Hospital, Cairo, Egypt.

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First Name

El-Shayeb

Last Name

M

MiddleName

-

Affiliation

Allergy and Immunology Department of Internal Medicine in Ain Shams University Hospital, Cairo, Egypt.

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Orcid

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First Name

Othman

Last Name

E

MiddleName

-

Affiliation

Allergy and Immunology Department of Internal Medicine in Ain Shams University Hospital, Cairo, Egypt.

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Orcid

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First Name

Elfawy

Last Name

N

MiddleName

-

Affiliation

Allergy and Immunology Department of Internal Medicine in Ain Shams University Hospital, Cairo, Egypt.

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Volume

21

Article Issue

1

Related Issue

3769

Issue Date

2005-10-01

Receive Date

2018-10-31

Publish Date

2005-10-01

Page Start

131

Page End

138

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 21_Issue 1_Pages 131-138.pdf

PDF . 253.1kB

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https://ejhm.journals.ekb.eg/article_18055.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18055

Order

11

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Angiotensin Converting Enzyme Gene Polymorphism in Egyptian Patients with Systemic Lupus Erythematosus

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Article

Created At

22 Jan 2023