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18052

Hypoglycemic And Hyperinsulinemic Effects Of Ferula Assafoetida On Diabetic Male Albino Rats

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Last updated: 03 Jan 2025

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Abstract

In the current study, thirty adult male albino rats were used to investigate the effect of Ferula assafoetida on carbohydrate metabolism in alloxan-induced diabetes. Rats were divided into three equal groups, control, diabetic non treated and diabetic Ferula assafoetida treated groups. After thirty days of treatment five rats of each group were sacrificed and the others were left without any additional treatment for another 15 days (recovery period) then were sacrificed. Body weight, blood glucose, serum insulin and liver glycogen content levels were determined for each rat at the end of each period. It was noticed that Ferula assafoetida treatment led to a significant improve in hyperglycemia, hypoinsulinemia, decreased liver glycogen and increased percentage of body weight change caused by alloxan. And this improvement was also seen after the recovery period. Ferula assafoetida treatment led also to marked improvement in the histopathological degenerative changes in the β cells of islets of Langerhans caused by alloxan after both the treated and recovery periods.

DOI

10.21608/ejhm.2005.18052

Authors

First Name

Eman G. E.

Last Name

Helal

MiddleName

-

Affiliation

ZoologyDepartment,FacultyofScience,Department Histology

Email

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City

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Orcid

-

First Name

Ashraf M.

Last Name

Mostafa

MiddleName

-

Affiliation

ZoologyDepartment,FacultyofScience,Department Histology

Email

-

City

-

Orcid

-

First Name

Amany F.

Last Name

MhMood

MiddleName

-

Affiliation

Facultyof Medicine Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Anwaar A.

Last Name

Kahwash

MiddleName

-

Affiliation

Nutrition and Food Science Department, Faculty of Home Economic , Jeddah, K.S.A.

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-

City

-

Orcid

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Volume

21

Article Issue

1

Related Issue

3769

Issue Date

2005-10-01

Receive Date

2018-10-31

Publish Date

2005-10-01

Page Start

95

Page End

108

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 21_Issue 1_Pages 95-108.pdf

PDF . 1.4MB

Link

https://ejhm.journals.ekb.eg/article_18052.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18052

Order

8

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Hypoglycemic And Hyperinsulinemic Effects Of Ferula Assafoetida On Diabetic Male Albino Rats

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Article

Created At

22 Jan 2023