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18045

Toxic effects of paroxetine on sexual and reproductive functions of rats

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Last updated: 03 Jan 2025

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Abstract

This study determined some appropriate parameters to detect male and female reproductive, endocrine, and teratological toxicity besides genotoxic effects of paroxetine. Several parameters concerning fertility were measured in male and female rats given oral doses of paroxetine ( 0.36mg/100g b.wt./day) for a month. In addition, estimation of the drug residues in male, female and fetus were carried out. There were alterations in serum concentration of gonadotraphins: FSH, LH, PRL and in the sex hormones : testosterone, progesterone and estradiol in male and female rats. These alterations were accompanied by sperm reduction, sperm abnormalities, irregular shaped of seminiferous tubules, hypertrophy of geominal cells and structural chromosomal aberrations in male rats. A reduction in mating and fertility indices were observed with an increase in the number of resorbed fetuses, and a decrease in body weight and crown rump length of rat embryos.

DOI

10.21608/ejhm.2005.18045

Authors

First Name

Inass

Last Name

EL-Gaafarawi

MiddleName

-

Affiliation

The National Center for Social and Criminological Research

Email

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City

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Orcid

-

First Name

Magdy

Last Name

Hassan

MiddleName

-

Affiliation

The National Center for Social and Criminological Research

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Fouad

MiddleName

-

Affiliation

Medico-Legal Administration,Cairo,Egypt.

Email

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City

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Orcid

-

First Name

Fathy

Last Name

El-Komey

MiddleName

-

Affiliation

The National Center for Social and Criminological Research

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-

City

-

Orcid

-

Volume

21

Article Issue

1

Related Issue

3769

Issue Date

2005-10-01

Receive Date

2018-10-31

Publish Date

2005-10-01

Page Start

16

Page End

32

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 21_Issue 1_Pages 16-32.pdf

PDF . 748.4kB

Link

https://ejhm.journals.ekb.eg/article_18045.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18045

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2

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Toxic effects of paroxetine on sexual and reproductive functions of rats

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Article

Created At

22 Jan 2023