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18044

Reldan and Ammonium Nitrate Induced Histopatjological and Fine Structural Changes in Testis of Mice

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Last updated: 03 Jan 2025

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Abstract

Two agrochemicals, reldan insecticide and ammonium nitrate fertilizer affected the histopathological and ultrastructural of mice testicular tissue. Mice were divided into 13 groups, the first group served as a control group while the other groups treated with reldan or ammonium nitrate. For each of the agrochemicals used, the 1⁄2 LD50 (12 mg/kg b.wt. for reldan and 90 mg/kg b.wt. for ammonium nitrate) was given as a single dose to 3 groups of mice which were sacrificed after 5, 10 and 15 days post-treatment, and as repeated daily doses to other groups of mice for 5 and 10 days. Animals treated for 5 days were sacrificed 24 hrs after the last dose, while those treated for 10 days were sacrificed 24 hrs or 5 days after the last dose. The applied agrochemicals caused histopathological changes in the testes including, disorganization of the basal lamina and germinal epithelium, maturation arrest at various degrees of degenerated spermatocytes and spermatids in the testicular tissue. Ultrastructural examination showed marked alterations and degeneration of organelles in germ cells, Sertoli cells and Leydig cells.

DOI

10.21608/ejhm.2005.18044

Authors

First Name

Mahmoud, A.

Last Name

El-Banhawy

MiddleName

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Affiliation

Zoology Depts, Faculty Science , Ain Shams University

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Orcid

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First Name

Nahed, H.A.

Last Name

Riad

MiddleName

-

Affiliation

Zoology Depts, Faculty Science , Ain Shams University

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City

-

Orcid

-

First Name

Mona

Last Name

El-Akkad

MiddleName

-

Affiliation

Zoology Depts, Faculty Science , Ain Shams University

Email

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City

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Orcid

-

First Name

Shadia, A.

Last Name

Radwan

MiddleName

-

Affiliation

Biology & Geology Depts, Faculty of Education, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Aziza

Last Name

El-Wessemy

MiddleName

-

Affiliation

Biology & Geology Depts, Faculty of Education, Ain Shams University

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Volume

21

Article Issue

1

Related Issue

3769

Issue Date

2005-10-01

Receive Date

2018-10-31

Publish Date

2005-10-01

Page Start

1

Page End

15

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 21_Issue 1_Pages 1-15.pdf

PDF . 2.4MB

Link

https://ejhm.journals.ekb.eg/article_18044.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18044

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Reldan and Ammonium Nitrate Induced Histopatjological and Fine Structural Changes in Testis of Mice

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Article

Created At

22 Jan 2023