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18104

Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.

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Last updated: 24 Dec 2024

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Abstract

The toxicity of tizanidine and baclofen was studied on male rats. The oral clinical dose of tizanidine and baclofen( 0.216 and o.54 mg/ 100g body weight / day, respectively)was given for one, two, three and four weeks. Chronic administration of the two drugs causes damage to the lung and a significant reduction in serum and lung levels of GSH , Vit E , Vit C and SOD activity . Four weeks treatment induced significant elevation of GPX activity and MDA levels. The two drugs, also, caused inhibitory activity on proliferation of splenocyte triggered by Con A, LPS and IL-2 production cell activities. They also produced several abnormal patterns in the EEG including increased epileptiform discharges and synchronous rhythmic activity . Diffuse slowing , with increased beta and delta activity and decreased alpha activity , with superimposed beta activity were recorded. than baclofen .  

DOI

10.21608/ejhm.2005.18104

Authors

First Name

Fathy

Last Name

El-Komey

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Affiliation

The National Center for Social and Criminological Research, Zamalek, P.O., P.C.11561, Cairo, Egypt.

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First Name

Inass

Last Name

EL-Gaafarawi

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Affiliation

The National Center for Social and Criminological Research, Zamalek, P.O., P.C.11561, Cairo, Egypt.

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Orcid

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First Name

Hanan

Last Name

Moustafa

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-

Affiliation

The National Center for Social and Criminological Research, Zamalek, P.O., P.C.11561, Cairo, Egypt.

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

196

Page End

215

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 196-215.pdf

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https://ejhm.journals.ekb.eg/article_18104.html

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https://ejhm.journals.ekb.eg/service?article_code=18104

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17

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Toxic Effects Of Some Antispastic Drugs on the EEG: Some Biochemical And Immunological Studies on Rats.

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Article

Created At

22 Jan 2023