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18102

Stevioside as A low caloric sweetener to milky drink and its protective role against oxidative stress in diabetic rats

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Last updated: 24 Dec 2024

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Abstract

Stevioside is a natural sweetener extract from the plant Stevia rebaudiana Bertoni. Stevioside was used in traditional medicine among Indian community in Brazil for the treatment of diabetes. The present study aimed to investigate the safety of stevioside as natural sweetener substitute sugar in a dairy product needed by those suffering from diabetes and its protctive role against oxidative stress exerted by hyperglycemia. The antibacterial activity of stevioside showed no effect on the pathogenic bacteria namely S. aureus, S. typhomuium and E. coli as well as lactic acid bacteria. In the present study hyperglycemia was induced by i.p. injection of alloxan in two successive doses (70 mg/kg b.w. eash / day to rats preadministered stevioside in two different doses (640 mg/kg b.w. and 1.280 g/kg b.w.) for eight weeks. The following investigations were carried out, glucose tolerance test, blood glucose, blood glutathione, MDA, erythrocyte SOD and transminases. The histopathological examinations were performed at the end of the experimental period. The results obtained in this study assessed the safety and protective role of stevioside as a natural sweetener substitute sugar in a dairy product.

DOI

10.21608/ejhm.2005.18102

Authors

First Name

Ayman M.

Last Name

Badawi

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Affiliation

Department of Biochemistry National Organization For Drug Control And Research (NODCAR) P.O. Box 29, Cairo, Egypt.

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First Name

Nadia A.

Last Name

El-tablawy

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Affiliation

Department of Biochemistry National Organization For Drug Control And Research (NODCAR) P.O. Box 29, Cairo, Egypt.

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First Name

Nahed S.

Last Name

Bassily

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Affiliation

Department of Histology National Organization For Drug Control And Research (NODCAR) P.O. Box 29, Cairo, Egypt.

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Orcid

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First Name

Sami A.

Last Name

El-Behairy

MiddleName

-

Affiliation

Department of Food Evaluation and Food Science National Organization For Drug Control And Research (NODCAR) P.O. Box 29, Cairo, Egypt.

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

163

Page End

176

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 163-176.pdf

PDF . 500.9kB

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https://ejhm.journals.ekb.eg/article_18102.html

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https://ejhm.journals.ekb.eg/service?article_code=18102

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Stevioside as A low caloric sweetener to milky drink and its protective role against oxidative stress in diabetic rats

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Article

Created At

22 Jan 2023