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18101

Effect of Commiphora myrrha extract on some physiological parameters and histological changes in diabetic albino rats.

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Last updated: 24 Dec 2024

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Abstract

The present study aimed to clarify the antidiabetic activity of Commiphora myrrha (CM) aqueous extract on thirty adult male albino rats, which were divided into two groups; the first served as a control group, the second was injected with alloxan (120mg/Kg body weight) and divided into two subgroups the first served as diabetic group, the second treated with (CM) water extract (0.05mg/100 gm bwt). After 30 days of the treatment half of each group was sacrificed and the other half was left for other 15 days without any additional treatment (recovery period). Our results revealed highly significant decrease (p< 0.01) in blood glucose level and highly significant increase in body weight of the diabetic rats with different histological changes in cells of islets of Langerhans. These histological and physiological changes were ameliorated in rats treated with CM. Water extract of CM has a definite hypoglycemic, hyperinsulinimic effect, on the other hand, a significant increase in body weight, β cell number and liver glycogen contents were achieved. The results of the present study clarify the role of CM as an active antidiabetic plant and suggest a relationship between drenching CM extract and insulin production. Other of investigations want be done to detect effects of different doses and time intervals of CM in diabetic animals.

DOI

10.21608/ejhm.2005.18101

Authors

First Name

Eman G.E.

Last Name

Helal

MiddleName

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Affiliation

Zoology Department, Faculty of Science ,Al-Azhar, University.

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Orcid

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First Name

Ashraf

Last Name

Mahmoud

MiddleName

-

Affiliation

Histology Department, Faculty of Medicine, Al-Azhar, University.

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Orcid

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First Name

Essam E.

Last Name

El-Badawy

MiddleName

-

Affiliation

Anatomy Department, Faculty of Medicine, Tanta University.

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-

City

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Orcid

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First Name

Anwaar A.

Last Name

Kahwash

MiddleName

-

Affiliation

Zoology Department, Faculty of Science ,Al-Azhar, University.

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

148

Page End

162

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 148-162.pdf

PDF . 1.5MB

Link

https://ejhm.journals.ekb.eg/article_18101.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18101

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14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Commiphora myrrha extract on some physiological parameters and histological changes in diabetic albino rats.

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Article

Created At

22 Jan 2023