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18096

Biochemical Effects Of Ribavirin (Antiviral) And Ddb (Hepato Protective) Drugs In Albino Rats

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Last updated: 24 Dec 2024

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Abstract

The present investigation has been designed to through spot light on the efficiency of these two drugs in treatment of hepatitis patients. Cortisol, antigliadin (1gG) , total protein (TP) albumin (ALB) , Iron (Fe) , alanine aminotransferase (ALT) , aspartic aminotransferase (AST) and alkaline phosphatase (ALP) were determined in serum of normal mature male and female albino rats that injected intraperitoneally day after day with 1mg/kg body weight of each drug separately for 3 months. The cortisol level and ALP showed significant increase in each of ribavirin or DDB treated animals, while the IgG concentration in ribavirin treated animals increased significantly, but it is did not vary greatly from that of the control in DDB treated animals. On the other hand both ribavirin and DDB treated male and female rats showed significant decrease in the ALT in serum while serum AST elicited non significant decrease in each of ribavirin and DDB treated male and female. With respect to serum TP and ALB levels the result showed significant decrease in ribavirin and non significant decrease in DDB treated male and female rats. Furthermore, the serum Fe level in ribavirin treated male and female rats increased significantly but it is did not vary greatly from that of the control in DDB treated animal.

DOI

10.21608/ejhm.2005.18096

Authors

First Name

Soliman S.

Last Name

Ibrahim

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

Email

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City

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Orcid

-

First Name

Amr

Last Name

Shalaby

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

Email

-

City

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Orcid

-

First Name

Mahmoud

Last Name

Rabeh

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Zagazig University

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-

City

-

Orcid

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

83

Page End

93

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 83-93.pdf

PDF . 417.3kB

Link

https://ejhm.journals.ekb.eg/article_18096.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18096

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9

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Biochemical Effects Of Ribavirin (Antiviral) And Ddb (Hepato Protective) Drugs In Albino Rats

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Article

Created At

22 Jan 2023