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18093

Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity

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Last updated: 03 Jan 2025

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Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease of unknown etiology. The rheumatoid synovium is characterized by infiltration of T cells, macrophage, B cells, and proliferating fibroblasts which aggressively invade cartilage and bone, thus destroying joints' ability to function. In rheumatoid arthritis (RA) both an imbalance between excessive production of the proinflamatory and ant-inflammatory cytokines and skewing of the T cell to a T helper like response. Cytokines have been shown to play a modulatory role in the pathogenesis of RA. The imunoregulatory cytokine IL-10 increases autoantibody production by B cell stimulates its survival, proliferation and differentiation. Moreover IL-10 inhibits the generation of proinflamatory cytokines and proliferation of T helper lymphocyte. Interleukin 16 might play a role in the pathogenesis of chronic inflammation in RA. It has a proinflammatory properties by promoting recruitment of T cells into the rheumatoid synovium. Also IFN-γ is of interest because of the role it plays in the initiation and perpetuation of T helper cell . Serum level of IL-10, IL-16, and IFN-γ were determined in patients with rheumatoid arthritis in relation to disease activity. All patients with RA (n=30) showed highly significant increase in ESR, CRP, IL-10, IL- 16, IFNγ compared to control group (p<0.01). Positive correlation were found between IL-10 and each IL-16 and IFN-γ (p<0.001) (r=0.63, 0.55) respectively, and highly significant correlation between IL-16 and IFNγ (p<0.001) (r=0.89)were determined. Results showed positive correlation between ESR and each IL-10, IL-16, IFNγ (p<0.001) (r=0.67, 0.87, 0.75) respectively. And highly significant correlation between CRP and each IL- 10, IL-16, IFNγ (p<0.001) (r=0.0.71, 0.83, 0.73) which indicate relation between increase level of cytokine with disease activity. These data suggest that there is increased production of IL-10, IL-16, and IFN-γ in patients with rheumatoid arthritis, and that it is correlated with the disease activity. These cytokines are interesting for further research inflammatory disease.

DOI

10.21608/ejhm.2005.18093

Authors

First Name

Eman.M.

Last Name

Abdel Rahman

MiddleName

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Affiliation

Clinical pathology& Internal Medicine Departments, Faculty of Medicine for girls, Al Azhar University

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City

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Orcid

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First Name

Hamdia.

Last Name

Ezzat

MiddleName

-

Affiliation

Clinical pathology& Internal Medicine Departments, Faculty of Medicine for girls, Al Azhar University

Email

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City

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Orcid

-

First Name

Maha M

Last Name

Abdel Mohsen

MiddleName

-

Affiliation

Clinical pathology& Internal Medicine Departments, Faculty of Medicine for girls, Al Azhar University

Email

-

City

-

Orcid

-

First Name

Karema

Last Name

Yosef

MiddleName

-

Affiliation

Clinical pathology& Internal Medicine Departments, Faculty of Medicine for girls, Al Azhar University

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Orcid

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

46

Page End

57

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 46-57.pdf

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https://ejhm.journals.ekb.eg/article_18093.html

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https://ejhm.journals.ekb.eg/service?article_code=18093

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Original Article

Type Code

606

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Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Interleukin-10, Interleukin- 16 and Interferon-γ in serum of patients with rheumatoid arthritis and correlation with disease activity

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Article

Created At

22 Jan 2023