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18091

Hypoglycemic Effect Of Concomitant Administration Of Erythromycin And Tolbutamide In Alloxan-Induced Diabetes In Rats

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Last updated: 03 Jan 2025

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Abstract

Erythromycin is among the antibiotics that have widespread use for treatment of community and hospital-acquired infections. Although uncommon, hypoglycemia has been reported with erythromycin and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who are receiving therapy with oral hypoglycemics. The present study was designed to explore the potential effects of erythromycin on glucose metabolism in experimental animals In the present work, alloxan was used to induce diabetes in a dose of 200 mg/kg body weight, intraperitoneally, in rats. The blood glucose level after alloxan was measured. Tolbutamide lowered blood glucose level in normal and hyperglycemic rats. Erythromycin produced lowering of blood glucose level in non diabetic rats and also, significantly potentiated the hypoglycemic action of tolbutamide in diabetic rats.

DOI

10.21608/ejhm.2005.18091

Keywords

Tolbutamide, Erythromycin, alloxan, Diabetes mellitus

Authors

First Name

Amr, A.H.

Last Name

Rostom

MiddleName

-

Affiliation

departments of Pharmacology, Faculties of Medicine, (Cairo), Al-Azhar University

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Orcid

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First Name

Al Sayed, A.

Last Name

Zaki

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Affiliation

departments of Pharmacology, Faculties of Medicine, (Cairo), Al-Azhar University

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City

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Orcid

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First Name

Mohammed,

Last Name

H. El Bakry

MiddleName

-

Affiliation

Departments of Pharmacology, Faculties of Medicine, ( Asuit), Al-Azhar University

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

29

Page End

37

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 29-37.pdf

PDF . 256.7kB

Link

https://ejhm.journals.ekb.eg/article_18091.html

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https://ejhm.journals.ekb.eg/service?article_code=18091

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Hypoglycemic Effect Of Concomitant Administration Of Erythromycin And Tolbutamide In Alloxan-Induced Diabetes In Rats

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Article

Created At

22 Jan 2023