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18088

Serum level of Matrix metalloproteinase-9 in patients with systemic lupus erythematosus.

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Last updated: 24 Dec 2024

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Abstract

Background: Matrix metalloproteinase-9 (MMP-9) was involved in inflammation and immune system dysfunctions. Beside immunologic abnormalities, systemic lupus erythematosus (SLE) also presents chronic inflammatory components. Therefore, a role of MMP-9 in SLE pathology might be supposed. Objective: To investigate the level of matrix metalloproteinase-9 in systemic lupus erythematosus patients and to determine its value in monitoring disease activity. Patients and methods: Twenty five SLE female patients were included in this study. Ten healthy females where selected as controls. The activity of SLE was evaluated according to SLAM scoring. Using quantitative ELISA Kit provided from R & D system INC. USA, to quantitate the total levels of MMP-9 . These levels were then compared and correlated with the ANA, anti-ds-DNA, lupus nephritis, Raynaud phenomenon, malar rash, photosensitivity, alopecia, and mucosal ulcers. Results: serum of MMP-9 were found to be significantly higher (P<0.01), in SLE patients compared to the control group. Serum MMP-9 show statistical significant correlation with anti- ds DNA, Lupus nephritis, Raynaud phenomenon, malar rash and photosensitivity and it did not- show any statistical significant correlation with ANA, alopecia and mucosal ulcers Conclusion : The data suggest that MMP-9 could be involved in the pathogenesis of SLE, and serum MMP-9 can be used as marker progression and amelioration in SLE.

DOI

10.21608/ejhm.2005.18088

Authors

First Name

Ghada A.

Last Name

Abd El-Aziz

MiddleName

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Affiliation

Departments of Dermatology Faculty of Medicine for girls Al-Azhar university

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Orcid

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First Name

Hanan M.A.

Last Name

Darwish

MiddleName

-

Affiliation

Departments of Dermatology Faculty of Medicine for girls Al-Azhar university

Email

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City

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Orcid

-

First Name

Amal A.

Last Name

Morsy

MiddleName

-

Affiliation

Clinical pathology Faculty of Medicine for girls Al-Azhar university

Email

-

City

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Orcid

-

First Name

Sabila Gomma

Last Name

Mousa

MiddleName

-

Affiliation

General Medicine Faculty of Medicine for girls Al-Azhar university

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Volume

20

Article Issue

1

Related Issue

3768

Issue Date

2005-07-01

Receive Date

2018-10-31

Publish Date

2005-07-01

Page Start

1

Page End

7

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 20_Issue 1_Pages 1-7.pdf

PDF . 327.2kB

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https://ejhm.journals.ekb.eg/article_18088.html

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https://ejhm.journals.ekb.eg/service?article_code=18088

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum level of Matrix metalloproteinase-9 in patients with systemic lupus erythematosus.

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Article

Created At

22 Jan 2023