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18122

Active Immunization Of Rabbit With Gamma Irradiated Cobra (Naja haje) Venom Toxoid

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Last updated: 03 Jan 2025

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Abstract

Cobra (Naja haje) venom detoxified by gamma radiation (15KGy or 25KGy)
as toxoid for active immunization of rabbits following a short schedule ( on day 0, 7,21) of immunization with complete Freund's adjuvant. Effective neutralization of venom toxin by immune sera of rabbits was observed. The presence of antibody in the immune sera was detected by immuno-diffusion test. The non-irradiated and the two dose levels gamma irradiated Naja haje venom, against the antivenin antibody produced with non-irradiated venom or against antivenin antibody produced with 15 KGy gamma irradiated venom all showed similar patterns. Also there was no change in the titer of antivenin solution obtained from the rabbit immunized with 15KGy irradiated venom , as compared with that antivenin solution obtained from rabbit immunized with non-irradiated venom. Sera of rabbits immunized with 15KGy irradiated venom toxoid (15KGy toxoid antiserum) neutralized venom lethality, 95% of protease activity and 50% of phospholipase A2.

DOI

10.21608/ejhm.2005.18122

Authors

First Name

Esmat A.

Last Name

Shaban

MiddleName

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Affiliation

Department of Drug Radiation Research and Technology, Atomic Energy Authority

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Orcid

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Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

198

Page End

207

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 198-207.pdf

PDF . 309.9kB

Link

https://ejhm.journals.ekb.eg/article_18122.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18122

Order

18

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Active Immunization Of Rabbit With Gamma Irradiated Cobra (Naja haje) Venom Toxoid

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Article

Created At

22 Jan 2023