ManageChatDiscover
18121

Histological Study Of The Effect Of Zinc Sulphate On The Toxicity Of Aluminium Sulphate In Liver And Kidney Of Male Albino Rats

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Aluminium (Al) is one of the most abundant and important elements in the environment. In recent years, the production of this metal and its toxicity increased with its discharge into the environment. This study was designed to evaluate the effect of Al intake toxicity in liver and kidney tissues of albino rats and the role of zinc as a protective agent against Al toxicity. Fourty five male albino rats were divided into equal three groups. The first group of animals was considered as control. The animals in the second group were given (50mg/kg/day) of Al sulphate orally using gastric tube for 45 day. Third group were given Al sulphate (50mg/kg/day) followed by zinc sulphate (50mg/kg/day) orally as well as samples of liver and kidney tissues were obtained after 15, 30, 45 days of last doses respectively. Paraffin sections (5μm) were prepared for histological study stained with Haematoxylin & Eosin. The obtained histological results of the histological study of the second group showed that there were congested blood sinusoids and swelling of some hepatocytes within cytoplasm in which there were vacuoles, fragmented nuclei with some cellular infiltration. Kidney tissue showed shrinkage of some glomeruli and distortion of the tubular epithelial cells. Results in the third group, where zinc sulphate was added, showed amelioration and improvement in both liver and kidney tissues.

DOI

10.21608/ejhm.2005.18121

Authors

First Name

Azza M.

Last Name

Gawish

MiddleName

-

Affiliation

Department of zoology, Faculty of Science, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

189

Page End

197

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 189-197.pdf

PDF . 444.4kB

Link

https://ejhm.journals.ekb.eg/article_18121.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18121

Order

17

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Histological Study Of The Effect Of Zinc Sulphate On The Toxicity Of Aluminium Sulphate In Liver And Kidney Of Male Albino Rats

Details

Type

Article

Created At

22 Jan 2023