Beta
ManageSearchChatDiscover
18118

Interaction of sodium nitrite and sunset yellow and its effect on some biochemical parameters in young albino rats

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Children usually eat and drink food containing both food preservatives, as sodium nitrite and food colourants, as sunset yellow (S.S.Y) at the same time. The mixture of the two agents at the limited dose of each was found to be lethal. 1/10th of this dose was used daily for 30 days. Animals were divided into three groups. The first served as a control, while the second was orally administered a mixture of sodium nitrite (NaNO3) and S.S.Y. The third received garlic in addition to the above mixture. Half of the animals from each group were decapitated after 30 days of treatment, while the other half was left for another 15 days for recovery. Investigation of the mixture of sod.nitrite and S.S.Y significantly decreases protein and albumin. Significant increases were observed in cholesterol, gamma-glutamyltranspeptidase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK). No change was observed for Total protein, Triglyceride, aspartate aminotransferase (AST), alanine aminotransferase(ALT) and acid phosphatase (AcP) recorded. A complete recovery from the abnormalities of most biochemical parameters was observed after the recovery period or when garlic was administered. This draws attention to the dangers of interactions of such preservatives and colourants. The present study showed that even the permitted doses of colourants and food preservatives may be harmful. And illustrate that usage of garlic may ameliorate some of the expected hazards of food additions.  

DOI

10.21608/ejhm.2005.18118

Keywords

Garlic, NaNO3, sunset yellow

Authors

First Name

Eman G.E.

Last Name

Helal

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University (Girls)

Email

-

City

-

Orcid

-

First Name

Mervat

Last Name

Abdel-Rahman

MiddleName

-

Affiliation

Clinical Pathology Lab., Student Hospital, Cairo University, Giza

Email

-

City

-

Orcid

-

Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

156

Page End

167

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 156-167.pdf

PDF . 367.8kB

Link

https://ejhm.journals.ekb.eg/article_18118.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18118

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Interaction of sodium nitrite and sunset yellow and its effect on some biochemical parameters in young albino rats

Details

Type

Article

Created At

22 Jan 2023