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18115

Effect Of Fractionated And Single Doses Gamma Irradiation On Certain Mammalian Organs

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Last updated: 03 Jan 2025

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Abstract

The present work aims to study the effect of fractionated and single dose whole body gamma irradiation on the liver, spleen and intestine of albino rats. 30 Male albino rats (100-120g) were used as experimental animals, they were divided into three groups: The first group consists of 10 rats served as control group (non irradiated), the second group (10 rats) were subjected to a single dose of irradiation (5Gy) and the third group (10 rats) were subjected to gamma of irradiation (5Gy) delivered at 5 successive exposures daily. Histological results showed serious histopathological disorders in the liver, spleen and intestine after exposure to the single dose of gamma irradiation (5Gy), manifested by inflammation and infiltration with mononuclear cells, haemorrhage, dilatation, congestion and widening of blood vessels and necrosis of cells with pyknotic nuclei. Exposure of rats to fractionated doses of whole body gamma irradiation (1Gy) up to 5Gy resulted in less severe histopathological disorders in liver, spleen and small intestine (jejunum), This indicates the beneficial use of fractionated doses in planning for radiotherapy in cancer patients, thus reducing the serious histopathological changes of radiation on the human tissues.

DOI

10.21608/ejhm.2005.18115

Authors

First Name

Nabila A. R.

Last Name

Abdel Motaal

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Affiliation

Radiation Biology National Centre for Radiation Research and Technology, Cairo, Egypt.

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First Name

Azza

Last Name

Abdel Maguid

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Affiliation

Radiation Health Research Departments, National Centre for Radiation Research and Technology, Cairo, Egypt.

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Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

111

Page End

122

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 111-122.pdf

PDF . 1.7MB

Link

https://ejhm.journals.ekb.eg/article_18115.html

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https://ejhm.journals.ekb.eg/service?article_code=18115

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect Of Fractionated And Single Doses Gamma Irradiation On Certain Mammalian Organs

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Article

Created At

22 Jan 2023