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18110

Effect Of Diazepam On The Prenatal Development Of Neuropil Of The Purkinje Cell Layer Of The Cerebellar Cortex Of The Rats Embryo (Electron Microscope Study)

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Last updated: 03 Jan 2025

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Abstract

Diazepam is one of the most widely used sedative hypnotic agents, and many women take this drug during pregnancy. The purpose of this study was to investigate the effects of diazepam on the development of the neuropil of the Purkinje cell layer of the cerebellar cortex.
Twenty female pregnant rats were used in this study. The rats were divided into two groups, the first group (5 rats) was used as control group and the second group (15 rats) were given 10 mg/kg/day of diazepam orally and sacrificed at 15th, 20th, 25th days of pregnancy. It was difficult to differentiate between the dendrites and the axonal knobs at 15th day of pregnancy. As age advanced, the dendrites were swollen with absence of cytoplasmic organelles or contained few free ribosomes and immature mitochondria. The observed axonal knobs contained ill-defined synaptic vesicles. Immature axo-dendritic synapses were recognized on the 15th and 20th days of pregnancy, while on the 25th days of pregnancy symmetrical axo-dendritic synapses were recognized. From this study, it appears that the exposure to diazepam causes marked changes on prenatal development of neuropil of the Purkinje cell layer of the cerebellar cortex. Aim of the work The aim of the work was to study the effects of diazepam on the development of the neuropil of Purkinje cell layer of the cerebellar cortex.

DOI

10.21608/ejhm.2005.18110

Authors

First Name

Lotfy

Last Name

Sayed

MiddleName

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Affiliation

Histology Department Faculty of Medicine, Al-Azhar University

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Orcid

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First Name

Mamdoh

Last Name

Ghalli

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-

Affiliation

Histology Department Faculty of Medicine, Al-Azhar University

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Orcid

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First Name

Essam El-Din

Last Name

Abdelhady

MiddleName

-

Affiliation

Anatomy Department Faculty of Medicine, Al-Azhar University

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Orcid

-

First Name

Ola

Last Name

Abdelhamid

MiddleName

-

Affiliation

Anatomy Department Faculty of Medicine, Al-Azhar University (Girls)

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Orcid

-

First Name

Reda

Last Name

Awadalla

MiddleName

-

Affiliation

Anatomy Department Faculty of Medicine, Al-Azhar University

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Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

58

Page End

66

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 58-66.pdf

PDF . 924.4kB

Link

https://ejhm.journals.ekb.eg/article_18110.html

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https://ejhm.journals.ekb.eg/service?article_code=18110

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect Of Diazepam On The Prenatal Development Of Neuropil Of The Purkinje Cell Layer Of The Cerebellar Cortex Of The Rats Embryo (Electron Microscope Study)

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Article

Created At

22 Jan 2023