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18108

Effect of some medicinal plants on liver and kidney functions in diabetic albino rats

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Last updated: 24 Dec 2024

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Abstract

The present study aimed to clarify the effect of aqueous extracts of five plants (Nigella sativa , Aloe vera, Ferula assafoetida, Boswellia carterii Birdw and Commiphora myrrha) and their mixture on liver and kidney functions and protein profiles. Eighty adult male albino rats were divided into eight groups, the first served as control group, other groups were injected with alloxan(120mg/kg b.wt). The second group served as diabetic rats, the third were treated with a mixture (0.1g/100g b.wt), the fourth was treated with Nigella sativa (0.1g/100g b.wt), the fifth was treated with Aloe vera (0.05 g/100g b.wt ), the sixth was treated with Ferula assafoetida (0.1g/100g b.wt), the seventh was treated with Boswellia carterri Birdw (0.1g/100g b.wt) and the eighth group was treated with Commiphora myrrha (0.05 g/100g b.wt ). After thirty days of treatment half of each group was decapitated and the other one was left for 15 days without any additional treatment as recovery period to followup their hazards if present. The results revealed highly significant increase (p<0.01) in serum transaminases (aspartate ( AST ) and alanine (ALT)), alkaline phosphates (ALP), total bilirubin, urea and creatinine and recorded highly significant decrease (p<0.01) in serum total protein , albumin and globulin concentrations in the diabetic group when compared with normal rates. Otherwise, all plants extracts treated groups showed insignificant changes in the previous parameters when compared with control one . It seams, therefore that the water extracts of these plants and their mixture have protective effect against the side effects of alloxan on liver and kidney.  

DOI

10.21608/ejhm.2005.18108

Keywords

Liver functions, kidney functions, diabetic Albino rats

Authors

First Name

Eman G. E.

Last Name

Helal

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Al-Azher University (Girls)

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Orcid

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First Name

Anwaar A.

Last Name

Kahwash

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azher University (Girls)

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City

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Orcid

-

First Name

Ashraf

Last Name

Mahmoud

MiddleName

-

Affiliation

Histology Department, Faculty of Medicine, Al-Azher University

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City

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Orcid

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First Name

Mervat

Last Name

Abdel-Rahman

MiddleName

-

Affiliation

Clinical Pathology Lab., Student Hospital, Cairo University, Giza.

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Volume

19

Article Issue

1

Related Issue

3767

Issue Date

2005-04-01

Receive Date

2018-10-31

Publish Date

2005-04-01

Page Start

34

Page End

47

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 19_Issue 1_Pages 34-47.pdf

PDF . 424.0kB

Link

https://ejhm.journals.ekb.eg/article_18108.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18108

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of some medicinal plants on liver and kidney functions in diabetic albino rats

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Article

Created At

22 Jan 2023