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18151

Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women

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Last updated: 24 Dec 2024

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Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune disease commonly occurs in of childbearing age, with connective tissue inflammation particularly joints and causes characteristic rashes. Subjects & Methods: the present study includs30 premenopausal females, they were divided into 3 groups. Group I consists o ten premenopausal females without SLE, Group II include ten premenopausal females had SLE,disease duration less than three years, Group III include ten premenopausal females had SLE,disease duration more than three years. Bone mineral density (BMD) in the heel of right foot by Achilles Express in all groups had been performed. Estimation of the serum level of Dehydroepiandrosterone Sulphate (DHEA-S) hormone and serum level of calcium, phosphorous ,sodium and potassium. Results: the results of the present study showed that in group II the BMD was 10% with osteoporotic , 40% with osteopenic and 50% with normal BMD, group III the BMD was 10% with osteoporotic , 60% with osteopenic and 30% with normal BMD. The correlations were done between BMD and serum minerals calcium, phosphorous, sodium and potassium in SLE patients ( Group II&III). Statistically high significant increase was found among osteopenic versus control women. Moreover a significant increase of serum calcium and sodium while there was a significant decrease in serum DHEA-S, phosphorous and potassium. Conclusions: There is a relationship between level of DHEA and the progression of SLE. Moreover there is relation between the decline in serum levels of DHEA-S and phosphorous , and the elevation of serum levels of calcium and the occurrence of osteoporosis in SLE. Treatment with DHE is beneficial in controlling of the disease activity in LES patients.

DOI

10.21608/ejhm.2005.18151

Authors

First Name

El Shafaey

Last Name

M

MiddleName

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Affiliation

Internal Medicine Department. Faculty of Medicine, Ain Shams University

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First Name

Eman G.E.

Last Name

Helal

MiddleName

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Affiliation

Zoology Department. Faculty of science Al Azhar, University.

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Orcid

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First Name

Hala H.

Last Name

Elsayed

MiddleName

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Affiliation

Zoology Department. Faculty of science Al Azhar, University.

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Orcid

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First Name

Abeer S.M.

Last Name

Gawish,

MiddleName

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Affiliation

Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of dentistry (girls) Al Azhar, University.

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

171

Page End

185

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 171-185.pdf

PDF . 367.0kB

Link

https://ejhm.journals.ekb.eg/article_18151.html

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https://ejhm.journals.ekb.eg/service?article_code=18151

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16

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women

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Article

Created At

22 Jan 2023