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18148

Serological And Haematological Responses To Experimental Fascioliasis And Treatment

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Last updated: 03 Jan 2025

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Abstract

This study was established to evaluate and monitor both the humoral and haematological responses to Fascioliasis and its treatment in rabbit model. Rabbits were orally inoculated with viable F. gigantica metacercariae and then divided into four groups. Infected rabbits were orally administered a single dose of Triclabendazole (TCBZ) (10 mg kg-1) at week 4, 8 or 12 post- infection (pi), respectively. Antibody (Ab) response against infection was monitored using enzyme linked immunosorbant assay (ELISA). Total red blood cell counts (Rbcs), haemoglobin content (Hb) and total and differential white blood cells (Wbcs) were also determined. Infected rabbits were found to produce Ab against excretory-secretory products (ESP) of adult flukes two weeks pi where ELISA enabled the early diagnosis of infection. Ab level reached to the peak at week 10 pi. In TCBZ-treated groups, the early Ab responses prior to treatments were similar to response of infected-untreated rabbits. But, after different treatment regimens, Ab levels showed a significant decreases that were depended mainly on both time and hence efficacy of the treatment. In addition, significant reductions in both Rbcs and Hb values accompanied with mild anemia were found among infected group at week 12 &10 pi, respectively. TCBZ-treatment prevented the development of anaemia. Eosinophil numbers significantly increased starting from week 2 pi and peaking at week 4 or 6 pi in all groups. Hence, both eosniophilia and anaemia might be characteristic aspects for experimental fascioliasis.  

DOI

10.21608/ejhm.2005.18148

Keywords

Fascioliasis, Triclabendazole, enzyme linked immunosorbant assay, Haematology

Authors

First Name

Nour El Din H.

Last Name

Sherif

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

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Orcid

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First Name

Ismail M.

Last Name

Shalaby

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

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City

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Orcid

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First Name

Maha F.

Last Name

Soliman

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

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City

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Orcid

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First Name

Mohamed G.

Last Name

Hassan

MiddleName

-

Affiliation

Parasitology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.

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Orcid

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

124

Page End

132

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 124-132.pdf

PDF . 374.3kB

Link

https://ejhm.journals.ekb.eg/article_18148.html

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https://ejhm.journals.ekb.eg/service?article_code=18148

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serological And Haematological Responses To Experimental Fascioliasis And Treatment

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Article

Created At

22 Jan 2023