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18147

Effect of food preservative and food coloring agent on some physiological and hematological parameters in albino rats and the protective role of garlic

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Last updated: 24 Dec 2024

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Abstract

Most children, in the age of nursery consume food that contains both colorants and preservatives with great amount. This observation led us to study the interaction between sodium nitrite as a food preservative and sun set yellow as a coloring agent. The mixture of the two agents at the limited dose of each was found to be a lethal dose. So, 1/10th of this dose was used daily for 30 days. Animals were divided into three groups. The first group served as a control, while the second group was orally administered a mixture of 10 mg sod.nitrite (NaNO3)/kg mixed with 0.5 mg/kg/day sun set yellow (S.S.Y). The third group received garlic (5 mcg/kg) in addition to the above mentioned mixture. After 30 days of treatment, half of the animals from each group were decapitated. The other half of the animals was left for another 15 days without any additional treatment as a recovery period. Ingestion of the mixture of (NaNO3 and S.S.Y) significantly decreased rat body weight, RBCs and WBCs counts, Hb%, Hct%. No changes were recorded for organ/ body weight, respiratory rate, heart rate, rectal temperature. A complete recovery from the abnormalities of most physiological and hematological parameters was observed after the recovery period or when garlic was administered.

DOI

10.21608/ejhm.2005.18147

Keywords

Garlic, antioxidant, preservatives, colorants

Authors

First Name

Eman G.E.

Last Name

Helal

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Al- Azhar University (Girls).

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Orcid

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First Name

Mervat

Last Name

Abdel- Rahman

MiddleName

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Affiliation

Clinical Pathology Lab., Student Hospital, Cairo University

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

116

Page End

123

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 116-123.pdf

PDF . 332.0kB

Link

https://ejhm.journals.ekb.eg/article_18147.html

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https://ejhm.journals.ekb.eg/service?article_code=18147

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12

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of food preservative and food coloring agent on some physiological and hematological parameters in albino rats and the protective role of garlic

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Article

Created At

22 Jan 2023