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18146

Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopical

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Last updated: 24 Dec 2024

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Abstract

Cancer has become an important topic in medicine since it is a major cause of death in the developing countries and it is now only secondary to that of myocardial infraction. Nitrosamines precursors are known to be carcinogenic to humans, in various organs at relatively low levels of exposure. It induces benign and malignant tumors especially liver tumors following its administration by various routes, including ingestion and inhalation. Humans may be exposed to Nitrosamines through the ingestion of food that contains it, such as cured meat products, and smoked fish. Other exposures to Nitrosamines may be from drinking contaminated water and from breathing cigarette smoke and contaminated ambient air. Individual are most likely to be exposed to Nitrosamines in occupational settings such as in the rubber, tannery, fish processing, dyes, and surfactant industries. The prevalence of liver tumors throughout the world makes in imperative to seek chemo preventive agents. Vegetables, natural products of plant origin and numerous non-nutritive dietary constituents have been shown to play a salutary role in cancer chemoprevention. The present study aims to evaluate the chemo preventive efficacy of soy bean and Nigella sativa on hepato- carcinogenesis induced by dibuty1 nitrosamine (DEN). It could be observed that both soy bean and Nigella sativa have a good effect of amelioration against liver hepatoma induced by nitrosamine. Soy bean more or less showed more prerogative effect than Nigella 9 and 12 months after administration.

DOI

10.21608/ejhm.2005.18146

Authors

First Name

Hanaa F.

Last Name

Waer

MiddleName

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Affiliation

National center for radiation research and Technology Atomic Energy Authority Cairo Egypt

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Orcid

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First Name

Abdel Baset

Last Name

EL Asser

MiddleName

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Affiliation

Cancer Biology Depart. Cancer Institute, Cairo University

Email

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City

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Orcid

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First Name

Hamdy A.

Last Name

Ibrahim

MiddleName

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Affiliation

Zoology Depart. Faculty of science Mansora and Cairo University Cairo

Email

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City

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Orcid

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First Name

Maher M.

Last Name

Khalifa

MiddleName

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Affiliation

Zoology Depart. Faculty of science Mansora and Cairo University Cairo

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City

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Orcid

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First Name

Saad M

Last Name

Elgendy

MiddleName

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Affiliation

Cancer Biology Depart. Cancer Institute, Cairo University

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City

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Orcid

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First Name

Khaled I.

Last Name

Magrabi

MiddleName

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Affiliation

Zoology Depart Faculty of Medical Technology Alfatah University Libya

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Orcid

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

88

Page End

115

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 88-115.pdf

PDF . 2.1MB

Link

https://ejhm.journals.ekb.eg/article_18146.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18146

Order

11

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study)

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Article

Created At

22 Jan 2023