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18139

Clastogenic Effect of Azadirachtin of Neemix-4.5 On SWR/J Mouse Bone Marrow Cells

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Last updated: 03 Jan 2025

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Abstract

The clastogenic effect of azadirachtin of neemix-4.5 was investigated in SWR/J mouse bone marrow cells. Males and females, 5 each per treatment time, aged 10–12 weeks and weighing 31.7–33.8 g, were orally administrated 9.0 mg/kg (1/10 LD50) of azadirachtin solution. A control group (5 males and 5 females) received only sterile distilled water. The animals were sacrificed 6, 12, 24, 48 or 72 h post- treatment. The chromosome preparations were obtained from bone marrow cells. Chromatid and chromosomal aberrations were investigated in 50 metaphases per animal. No significant differences in the frequency of chromosomal aberrations or in the percentage of mitotic index were observed between the treated male and female mice at any time intervals used. Hence, data from the two sexes were pooled when analyzed statistically. In the prersent study, the dose level 9.0 mg/kg body weight of azadirachtin of neemix-4.5 did not induce any significant (p>0.05) changes in the percentages of mitotic indices or in chromosomal aberrations in the bone marrow cells of treated animals at all time intervals tested compared with the control group. As the pharmacokinetics of azadirachtin is unknown, the essentially negative results in the present study may be due to a lack of genotoxic potential .  

DOI

10.21608/ejhm.2005.18139

Keywords

Neemix-4.5, Azadirachtin, Clastogenic effect, Bone Marrow Cells, Mice

Authors

First Name

F. M.

Last Name

Abou-Tarboush

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Affiliation

King Saud University, College of Science, Department of Zoology, P.O. Box 2455, Riyadh 11451, Saudi Arabia

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First Name

H. M.

Last Name

El-Ashmaoui

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Affiliation

National Research Center, Cell Biology Dept., Giza, Egypt

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Orcid

-

First Name

H. I.

Last Name

Hussein

MiddleName

-

Affiliation

King Saud University, College of Sciences of Foods and Argriculture, Plant Protection Dept, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

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Orcid

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First Name

D.

Last Name

Al-Rajhy

MiddleName

-

Affiliation

King Saud University, College of Sciences of Foods and Argriculture, Plant Protection Dept, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

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First Name

M.

Last Name

Al-Assiry

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-

Affiliation

King Saud University, College of Sciences of Foods and Argriculture, Plant Protection Dept, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

23

Page End

28

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 23-28.pdf

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Link

https://ejhm.journals.ekb.eg/article_18139.html

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https://ejhm.journals.ekb.eg/service?article_code=18139

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Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Clastogenic Effect of Azadirachtin of Neemix-4.5 On SWR/J Mouse Bone Marrow Cells

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Article

Created At

22 Jan 2023