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18138

Protective Effect Of Ascorbic Acid On Cisplatin Genotoxicity In Male Mice Bone Marrow Cells

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Last updated: 03 Jan 2025

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Abstract

Cisplatin (cis-diamminedichloroplatinum II) is an effective antitumor agent with a wide spectrum of activity against varies solid tumors, but it has serious side effects on nontumour cells. Cisplatin produces intra- and interstrand DNA cross-linking effects and chromosomal aberrations in mammalian cells. Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. Pretreatment administration of ascorbic acid on cisplatin induced chromosome aberrations has been determined in bone marrow cells of Swiss albino mice. Results showed that cisplatin (7.5 & 10mg/kg bw)IP injection to male mice induced significant increase in the frequencies of chromosomal aberrations. The results of pre-treatment with ascorbic acid (66mg/kg bw) showed a significant decrease in the number of chromosomal aberrations induced with cisplatin tested doses. Ascorbic acid did not exhibit any clastogenic effect in male mice bone marrow cells. We concluded that ascorbic acid has a protective role against the genotoxicity induced by antitumor drug cisplatin.  

DOI

10.21608/ejhm.2005.18138

Keywords

Cisplatin- Antioxidants- Ascorbic Acid-Chromosomal Aberration- genotoxicity, Bone Marrow Cells- Mice

Authors

First Name

Nada, H.A.

Last Name

Al- Twaty

MiddleName

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Affiliation

Department of Biology, King Abdelaziz Universiy

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Orcid

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Volume

18

Article Issue

1

Related Issue

3766

Issue Date

2005-01-01

Receive Date

2018-11-01

Publish Date

2005-01-01

Page Start

16

Page End

22

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 18_Issue 1_Pages 16-22.pdf

PDF . 281.9kB

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https://ejhm.journals.ekb.eg/article_18138.html

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https://ejhm.journals.ekb.eg/service?article_code=18138

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Protective Effect Of Ascorbic Acid On Cisplatin Genotoxicity In Male Mice Bone Marrow Cells

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Article

Created At

22 Jan 2023