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18042

The Formation of Tetracycline in Date Medium by Mutants of Streptomyces aureofaciens Induced by Nitrosogiuanidine.

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Last updated: 24 Dec 2024

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Abstract

The present study deals with the genotoxicity of Nitrosoguanidine (N.T.G.) - a chemical mutagen- which was employed to induce auxotrophic mutations in the haploid wild type of bacteria Streptomyces aureofaciens strain NCIMB 8234. An increase in exposure time to the mutagen and dose of this mutagen led to a decrease in the survival percentage and increase in the percentage of mutation. The mutants were cultured in synthetic date fermentation medium, which contained Barni date-coat sugar extract as a carbon source. The following parameters were determined: final pH, medium quantity, and microbial cell biomass. All of the five mutants produced less antibiotic titers than the initial organism this was noticed after measuring the inhibition zone of each created for Staphylococcus aureus as a gram-positive pathogenic bacterium and Escherichia coli as a gram- negative pathogenic bacterium.

DOI

10.21608/ejhm.2006.18042

Authors

First Name

E. S.

Last Name

Ahmed

MiddleName

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Affiliation

Department of Cell Biology, National Research Center. Cairo, Egypt.

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First Name

Z. W.

Last Name

Sharawi

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Affiliation

Department of Biology. Faculty of Science, King Abdulaziz University. Jeddah, Saudi Arabia.

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Volume

22

Article Issue

1

Related Issue

3739

Issue Date

2006-01-01

Receive Date

2018-10-31

Publish Date

2006-01-01

Page Start

174

Page End

187

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 22_Issue 1_Pages 174-187.pdf

PDF . 576.1kB

Link

https://ejhm.journals.ekb.eg/article_18042.html

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https://ejhm.journals.ekb.eg/service?article_code=18042

Order

16

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Formation of Tetracycline in Date Medium by Mutants of Streptomyces aureofaciens Induced by Nitrosogiuanidine.

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Article

Created At

22 Jan 2023