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Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.

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Last updated: 03 Jan 2025

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Abstract

The current study aimed to clarify hazardous effect of ponceau 4R as food colour on rats and the effect of vitamin E as an antioxidant to prevent its toxic effect. Fourty premature growing male albino rats were divided into four groups, the first served as control group, the second supplemented with vitamin E (150 mg/kg),the third treated with ponceau 4R(0.19 mg/kg) and fourth treated with ponceau 4R(0.19 mg/kg) and vitamin E (150 mg/kg). Half of each group was treated for 3 m, the other half was treated for 6 months. Rats treated with ponceau 4R showed highly significant decrease (P<0.01) in serum total lipids, proteins, albumin levels and cholinesterase activity throughout the experimental period, while recorded a significant decrease (P<0.05) in glucose level till the end of the experiment and in globulin level and A/G ratio after 3 months of treatment only. On the other hand, significant increase was detected in total cholesterol level (P < .01) and AST activity (P < .05) after both periods of treatment, while ALT activity showed insignificant change. It seams from the presents study that vitamin E has protective effect against the side effect of ponceau 4R on rats.  

DOI

10.21608/ejhm.2006.18028

Keywords

Ponceau 4R, Vitamin E, food colour and antioxidant

Authors

First Name

Eman G. E.

Last Name

Helal

MiddleName

-

Affiliation

Departments of Zoology –Faculty of Science - Al-Azhar University(Girls)

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Orcid

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First Name

Mahmoud A.

Last Name

El-Kassas

MiddleName

-

Affiliation

Departments of Zoology –Faculty of Science - Al-Azhar University(Girls)

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Orcid

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First Name

Samer A. M.

Last Name

Zaahkouk

MiddleName

-

Affiliation

Departments of Zoology –Faculty of Science - Al-Azhar University(Girls)

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Orcid

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First Name

Hesham G.

Last Name

Abdel-Wahed

MiddleName

-

Affiliation

Departments of Zoology –Faculty of Science - Al-Azhar University(Girls)

Email

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City

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Orcid

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First Name

Amany F.

Last Name

Mahmoud

MiddleName

-

Affiliation

Faculty of Home Economics- jeddah, K.S.A.

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Volume

22

Article Issue

1

Related Issue

3739

Issue Date

2006-01-01

Receive Date

2018-10-31

Publish Date

2006-01-01

Page Start

73

Page End

79

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 22_Issue 1_Pages 73-79.pdf

PDF . 263.7kB

Link

https://ejhm.journals.ekb.eg/article_18028.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18028

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Some Biochemical Parameters Of Young Male Albino Rats Treated With Ponceau 4 R And Vitamin E.

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Article

Created At

22 Jan 2023