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18027

Antioxidant effect of parsley and panax ginseng extract standardized with ginsenosides Rg3 against alteration induced in reproductive functions in male mice

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Last updated: 03 Jan 2025

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Abstract

In the present study, the antigcidant effects of parsley oil and panax ginseng have been evaluated against the clastogenecity of ZEN. One hundred and eight mature male mice were distributed into nine treatment groups, including the control group and the groups treated with parsley oil (0.6 ml/kg b.w), panax ginseng extract (40 mg/kg b.w) or parsley oil plus panax ginseng extract with or without ZEN (10 μg/kg b.w). Animals within different treatment groups were divided into two subgroups (A and B). Subgroup A were used for the determination of serum testosterone levels and chromosomal aberrations and received their respective doses for two weeks whereas, subgroup B were used for sperm abnormality and received their respective doses twice a day for one week and sacrificed after 30 days. The results indicated that ZEN treatment resulted in a significant decrease in testosterone concentration, sperm count and sperm motility. Whereas it caused a significant increase in abnormal sperms counts and total chromosomal aberrations in germ cells. Animals treated with parsley oil or panax ginseng extract alone or in combination were comparable to the controls regarding all the tested parameters. The combined treatment with ZEN and parsley oil, panax ginseng or parsley oil plus panax ginseng extract resulted in a significant improvement in all tested parameters. Moreover, parsley oil was found to be effective than panax ginseng extract and the combined treatment was more effective than the single treatment. It could be concluded that both parsley oil and panax ginseng extract induced a protective action against ZEN-induced alteration in the reproductive performance and the combined treatment may be useful than the single treatment.

DOI

10.21608/ejhm.2006.18027

Keywords

zearalenone, parsley oil, panax and chromosomal aberration

Authors

First Name

Aziza M.

Last Name

Hassan

MiddleName

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Affiliation

Cell Biology Dept National Research Center, Dokki, Cairo, Egypt

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Orcid

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First Name

Mosaad A.

Last Name

Abdel-Wahhab

MiddleName

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Affiliation

Food Toxicology & Contaminants Dept. National Research Center, Dokki, Cairo, Egypt

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Volume

22

Article Issue

1

Related Issue

3739

Issue Date

2006-01-01

Receive Date

2018-10-31

Publish Date

2006-01-01

Page Start

60

Page End

72

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 22_Issue 1_Pages 60-72.pdf

PDF . 359.5kB

Link

https://ejhm.journals.ekb.eg/article_18027.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18027

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6

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Antioxidant effect of parsley and panax ginseng extract standardized with ginsenosides Rg3 against alteration induced in reproductive functions in male mice

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Article

Created At

22 Jan 2023