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Hydrated Sodium Calcium Aluminsilicate Protects Against Genotoxic Effects In Zeralenone-Treated Balb/C Mice

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Last updated: 03 Jan 2025

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Abstract

Zearalenone (ZEN) is a potent estrogenic metabolite mycotoxin produced by some Fusarium species. Few studies have been successfully employed to get rid of the ZEN contamination in foods. This study was conducted to evaluate the ability of hydrated sodium calcium aluminsilicate (HSCAS) to protect Balb/c mice against cytotoxicity and genotoxicity induced by ZEN. Mice were divided into nine experimental groups (12 mice/group) included the control group, the olive oil group, the groups treated orally with a single dose of HSCAS at doses level of 400, 600 and 800 mg/kg b.w, the group treated orally with a single dose of ZEN (40 mg/kg b.w), the group treated with ZEN plus HSCAS (400 mg/kg b.w), the group received Colchicin(4mg/kgbw)asapositivecontrolfor micronucleusassayandthegrouptreatedwith mitomycin C (1 mg/kg bw) as a positive control for chromosome aberrations assay. Forty eight hours after treatment, the femur and tibia were dissected out and bone marrow was obtained for different assays. The results showed that ZEN was cytotoxic and genotoxic to Balb/c mice as indicated by the increase in frequencies of polychromatic erythrocytes micronucleated (PCEMN) and chromosomal aberrations in bone marrow cells. The simultaneous administration of HSCAS with ZEN resulted in a decrease of PCEMN number and chromosomal aberrations frequency and increased the polychromatic erythrocytes (PCE) in bone marrow cells compared with the ZEN alone group. It could be concluded that HSCAS itself was safe at different tested doses and efficient in the prevention of ZEN induced clastogenicity in mice at a dose level as low as 400 mg/kg b.w.  

DOI

10.21608/ejhm.2006.18025

Keywords

HSCAS, zearalenone, Micronuclei, Chromosome aberrations, prevention

Authors

First Name

Samir

Last Name

Abbès

MiddleName

-

Affiliation

Laboratory of Environmental Immunology Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia

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Orcid

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First Name

Jalila Ben Salah-

Last Name

Abbès

MiddleName

-

Affiliation

Laboratory of Environmental Immunology Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia

Email

-

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Orcid

-

First Name

Zouhour

Last Name

Ouanes

MiddleName

-

Affiliation

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir , Tunisia

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-

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Orcid

-

First Name

Hassan

Last Name

Bacha

MiddleName

-

Affiliation

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir , Tunisia

Email

-

City

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Orcid

-

First Name

Omar

Last Name

Othman

MiddleName

-

Affiliation

Laboratory of Environmental Immunology Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia

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Orcid

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First Name

Mosaad A.

Last Name

Abdel-Wahhab

MiddleName

-

Affiliation

Food Toxicology & Contaminants Dept. Nationa l Research Centre, Dokki, Cairo, Egypt.

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Orcid

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First Name

Ridha

Last Name

Oueslati

MiddleName

-

Affiliation

Laboratory of Environmental Immunology Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia

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-

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-

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-

Volume

22

Article Issue

1

Related Issue

3739

Issue Date

2006-01-01

Receive Date

2018-10-31

Publish Date

2006-01-01

Page Start

49

Page End

59

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 22_Issue 1_Pages 49-59.pdf

PDF . 340.6kB

Link

https://ejhm.journals.ekb.eg/article_18025.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18025

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5

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Hydrated Sodium Calcium Aluminsilicate Protects Against Genotoxic Effects In Zeralenone-Treated Balb/C Mice

Details

Type

Article

Created At

22 Jan 2023