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17948

Beneficial Effect of Combined Administration of Vitamin C and Vitamin E in Amelioration of Chronic Lead Hepatotoxicity

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Last updated: 24 Dec 2024

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Abstract

Introduction: Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C and E against lead affects lipid hydroperoxide level and liver functions in male rats has been studied. Results: Administration of lead acetate (2%) in dirinking water for 3 months elevates plasma lipid hydroperoxide level, activities of aspartate aminotronsferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), cholesterol, triglycerides and low density lipoprotein (LDL) levels. On the other hand, reduced plasma glutathione (GSH), protein and high density lipoprotein (HDL) concentrations lowered significantly in lead (Pb) treated group. However, oral administration of vitamin C (Vit C) or vitamin E (Vit E) at dose level of 100 mg/kg body weight reduced the alterations in the previous parameters. On the other hand, co-administration of both vitamins (Vit C+ Vit E) to lead-treated rats led to the most significant decline in lipid hydroperoxide level, restoration of GSH level and exhibited more protection as compared with Vit C or Vit E separately. Conclusion: There is synergistic antioxidative effect between Vit C and Vit E that protects the liver from lead induced lipid peroxidation, suggesting that the antioxidant treatment may best be done using a balanced cocktail. .

DOI

10.21608/ejhm.2006.17948

Authors

First Name

Samir A.E.

Last Name

Bashandy

MiddleName

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Affiliation

Zoology Department, College of Science, King Saud univrsity Saudi Arabia

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Volume

23

Article Issue

1

Related Issue

3738

Issue Date

2006-04-01

Receive Date

2018-10-30

Publish Date

2006-04-01

Page Start

371

Page End

384

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 23_Issue 1_Pages 371-384.pdf

PDF . 496.0kB

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https://ejhm.journals.ekb.eg/article_17948.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17948

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17

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Beneficial Effect of Combined Administration of Vitamin C and Vitamin E in Amelioration of Chronic Lead Hepatotoxicity

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Article

Created At

22 Jan 2023