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17933

Protective Role Of Proanthocyanidin Against Carbon Tetrachloride Induced Toxicity In Irradiated Rats

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Last updated: 24 Dec 2024

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Abstract

The hepatic injury induced by carbon tetrachloride (CCl4 ) as well as gamma-irradiation has taken most attention. Prevention is one of the essential ways of controlling this toxicity and the use of natural plant compounds as grape seed extract can be considered as one of the most significant elements in this prevention. The present study is also designed to evaluate the hepatoprotective effects of grape seed extract (100mg/kg B.wt daily) against the toxic effect of CCl4 ( 0.3 ml/kg B.wt twice weekly for 8 weeks) and/ or fractionated doses of 2 Gy γ-radiation day after day up to 10 Gy in male rats. Results obtained could be summarized as follows: Combined treatments of CCl4 and γ- radiation induced a significant increase in malondialdehyde (MDA) level, and decreased level of reduced glutathione (GSH). It also increased serum enzymes aspartate transferase (AST), alanine transferase (ALT), aِِlkaline phosphatase (ALP) and gamma - glutamyl transpeptidase (γ-GT) activities and decreased Hb%, RBCs, WBCs and platelets count. Proanthocyanidin administration improved the significant increase in MDA level and ameliorated serum enzymes as well as improved the decreased level of GSH content of irradiated rats or those treated with CCl4. It also could normalize the blood constituents Hb%, RBCs, WBCs and platelets count. The data of the present study declared that proanthocyanidin is bioavailable, potent free radical scavenger and exhibits antioxidant properties against CCl4 and gamma-irradiation induced hepatic injury.

DOI

10.21608/ejhm.2006.17933

Authors

First Name

Mona A.

Last Name

El-Gawish

MiddleName

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Affiliation

National Center for Radiation Research and Technology-Atomic Energy Authority

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First Name

Amira T.

Last Name

Ebrahim

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Al-Azhar University

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Orcid

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First Name

Fatma A.

Last Name

Eid

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University

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Volume

23

Article Issue

1

Related Issue

3738

Issue Date

2006-04-01

Receive Date

2018-10-30

Publish Date

2006-04-01

Page Start

231

Page End

244

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 23_Issue 1_Pages 231-244.pdf

PDF . 491.0kB

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https://ejhm.journals.ekb.eg/article_17933.html

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https://ejhm.journals.ekb.eg/service?article_code=17933

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6

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Protective Role Of Proanthocyanidin Against Carbon Tetrachloride Induced Toxicity In Irradiated Rats

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Article

Created At

22 Jan 2023