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17922

Serum level of IL13 and expression of BCL2 in Behcet’s disease

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Last updated: 24 Dec 2024

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Abstract

Background BD: BCL2 family is a large family of apoptosis regulating proteins consisting of both blockers and promoters of cell death. Immunological processes and a variety of cytokines may play a role in pathophysiological process. Defective regulation of programmed cell death (apoptosis) also play a role in development of Behcet's disease Objective: To investigate the level of BCL2 and IL13in BD and to determine their to relation monitory disease activity. Patients and methods: This study was conducted on thirty patients (15 active and 15 inactive) and 15-health control, the activity of BD was evaluated according to international study group for BD disease, using ELISA technique for IL 13 and flow cytometry forBCL2. Results: Elevated serum levels of IL13 in patient with active BD than inactive and both had elevated levels than control(P< 0.01) and also the serum levels of Bcl2 was elevated in patient with active BD than inactive and control(P< 0.01).
Concolusion: The data suggested that IL13 and BCL2 could be involved in the pathogenesis of BD and its serum levels can be used as marker to monitor disease activity.

DOI

10.21608/ejhm.2006.17922

Authors

First Name

Hanan.M.A

Last Name

Darwish

MiddleName

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Affiliation

Departments of Dermatology and Venereology Faculty of Medicine for girls Al-Azhar University.

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First Name

Sabila Gomaa

Last Name

Mousa

MiddleName

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Affiliation

General Medicine Faculty of Medicine for girls Al-Azhar University.

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City

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Orcid

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First Name

Noha

Last Name

Hamdy

MiddleName

-

Affiliation

Clinical Pathology, Faculty of Medicine for girls Al-Azhar University.

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City

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Orcid

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First Name

Sahar

Last Name

Zalam

MiddleName

-

Affiliation

Clinical Pathology,Faculty of Medicine for girls Al-Azhar University.

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Volume

24

Article Issue

1

Related Issue

3737

Issue Date

2006-07-01

Receive Date

2018-10-30

Publish Date

2006-07-01

Page Start

548

Page End

555

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 24_Issue 1_Pages 548-555.pdf

PDF . 534.5kB

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https://ejhm.journals.ekb.eg/article_17922.html

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https://ejhm.journals.ekb.eg/service?article_code=17922

Order

12

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum level of IL13 and expression of BCL2 in Behcet’s disease

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Article

Created At

22 Jan 2023