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Assessment of Anticardiolipin antibodies, Circulating Lupus anticoagulant, Protein C, Protein S, Antithrombin III &Activated Protein C Resistance and Their Relation to Thomboembo

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Last updated: 24 Dec 2024

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Abstract

Background: Venous and arterial thrombosis occurs in patients with Behcet's disease and is associated with significant morbidity and mortality. Studies on a possible association between the occurrence of thrombosis and thrombophilia in patients with this disease have been controversial. The objective of this study was to assess the frequency and clinical relevance of anticardiolipin antibodies (aCL) & other thrombophilic factors and their relationship to thromboembolic & clinical manifestations in Behcet's disease (BD).
Materials and methods: IgG, IgM and IgA anticardiolipin antibodies (aCL) isotypes, presence of circulating lupus anticoagulant(LAC), protein C, protein S, antithrombin III & activated protein C resistance were investigated in 25 patients with BD and 25 patients with various rheumatic diseases not known to be associated with venous or arterial thromboembolic phenomena served as controls. Twelve of the patients with BD (48%) had either deep vein thrombosis (8 patients), arterial thromboembolic phenomena (4 patients), or both (2 patients). Results: The IgA aCL elevated in14 (56%) patients with BD compared with one (4%) patient in the control group (P<0.01). IgG aCL levels were elevated in 13 (52%) patients with Behcet's disease (BD) compared with one (4%) patient in the control group(P<0.01).Also patients with BD do not have decreased protein S, or antithrombin III activity, activated protein C resistance, circulating lupus anticoagulant (LAC), or elevated LgM aCL. No significant differences were found between any variable in both groups. No association between elevated IgMaCL levels and venous or arterial thrombosis and no statistical correlation was found between any factor and clinical manifestations of the disease. Conclusion: A significant number of patients have elevated levels of IgA& IgG aCL but they are not associated with venous or arterial thrombosis. These results do not suggest a primary role for aCL in BD and do not support the role of coagulation abnormalities in the pathogenesis of thromboembolic complications of Behcet's disease but suggest vascular inflammation as the main pathogenetic event in the vascular lesions in Behcet's disease.  

DOI

10.21608/ejhm.2006.17919

Keywords

Procoagulant factors, anticardiolipin antibodies, Thromboembolic manifestations, Behcet’s disease

Authors

First Name

Seham M. S.

Last Name

EL- Nakeeb

MiddleName

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Affiliation

Biochemistry Faculty of Medicine AL–Azhar University

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Orcid

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First Name

Ahmed M.

Last Name

Ragheb

MiddleName

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Affiliation

Clinical Pathology Faculty of Medicine AL–Azhar University

Email

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City

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Orcid

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First Name

H.S.

Last Name

El -Baz

MiddleName

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Affiliation

Clinical Pathology Faculty of Medicine AL–Azhar University

Email

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City

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Orcid

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First Name

Abdel ShafyA.

Last Name

H

MiddleName

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Affiliation

Rheumatology and Rehabilitation Dept. Faculty of Medicine AL–Azhar University

Email

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City

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Orcid

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First Name

A.M.

Last Name

Salama

MiddleName

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Affiliation

Chest Dept. Faculty of Medicine for Girls. AL–Azhar University

Email

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City

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Orcid

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First Name

Zeinab A.

Last Name

Zakzouk

MiddleName

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Affiliation

Chest Dept. Faculty of Medicine for Girls. AL–Azhar University

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City

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Orcid

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Volume

24

Article Issue

1

Related Issue

3737

Issue Date

2006-07-01

Receive Date

2018-10-30

Publish Date

2006-07-01

Page Start

539

Page End

547

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 24_Issue 1_Pages 539-547.pdf

PDF . 379.0kB

Link

https://ejhm.journals.ekb.eg/article_17919.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17919

Order

11

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Assessment of Anticardiolipin antibodies, Circulating Lupus anticoagulant, Protein C, Protein S, Antithrombin III &Activated Protein C Resistance and Their Relation to Thomboembolic and Other Clinical Manifestations in Behcet's Disease

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Article

Created At

22 Jan 2023