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The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy S

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Last updated: 03 Jan 2025

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Abstract

Foodadditivesarechemicalsubstancesaddedintentionallytofoodstuffstopreserve, color,sweetenandflavorfood.Monosodiumglutamate(MSG)isusedasaflavorenhancerand foundinmostsoups,saladdressingandprocessedmeat.TheuseofMSGinfoodisgrowing. Irrationalfearhadincreasedinthelastfewyearsduetotheadversereactionsandtoxicityof MSG.
ThepresentstudywasdesignedtoinvestigatetheeffectofMSGontheratliverandthe amelioratingeffectoftaurineanalog“Guanidinoethanesulfonicacid(GES)".Sixtyalbinorats (2-3monthsold)wereusedinthepresentstudy.MSGwasgivenorallyatadailydoseof60 mg/1000gforonemonth,twomonthsandwasgivenatadailydoseof100mg/1000gmforone month.TheresultsrevealedthatthedeleteriouseffectsofMSGweredoserelatedand cumulative.InMSGtreatedrats,theexaminedsectionsshowedremarkablealterationsvaried considerablyfrommoderatestructuralchangestocytoplasmiclysisandsignsofdegenerationof cellularorganelles.Thehistologicalchangesshoweddisturbedliverarchitecture,hemorrhagein thecentralveins,areasofnecrosis,vacuolationandincreasedinflammatorycellsinfiltration. Theglycogengranulesincreasedaswellasthecollagenfibersinthelivercells.Ultrastructural changesshowedlossofcytoplasmicdifferentiation,vacuolation,pyknoticnucleiwithirregular nuclearmembranesandelongatedelectrondensemitochondria.Conversely,treatmentofrats withtaurineanalog(GES)significantlyattenuatedthecellulartoxicityofMSG.

DOI

10.21608/ejhm.2006.17916

Authors

First Name

Hanaa F.

Last Name

Waer

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Affiliation

National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University

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First Name

Saleh

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Edress

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Affiliation

National Center for Radiation Research and Technology, Atomic Energy Authority Faculty of Medicine,Banha University

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Volume

24

Article Issue

1

Related Issue

3737

Issue Date

2006-07-01

Receive Date

2018-10-30

Publish Date

2006-07-01

Page Start

524

Page End

538

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 24_Issue 1_Pages 524-538.pdf

PDF . 2.3MB

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https://ejhm.journals.ekb.eg/article_17916.html

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https://ejhm.journals.ekb.eg/service?article_code=17916

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy S

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Article

Created At

22 Jan 2023