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Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy

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Last updated: 24 Dec 2024

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Abstract

Background: In the past, adipose tissue was largely regarded as a depot for fuel storage in the form of triglyceride. However, adipose tissue is an active endocrine organ that secretes a variety of metabolically important substances including adipokines. The adipocyte is now known to secrete a variety of proteins such as tumour necrosis factor (TNF)- , adipsin, plasminogen activator inhibitor-1, leptin, resistin, and adiponectin. Adipose tissue regulates insulin sensitivity via the circulating adipocytokines, resistin and adiponectin. These factors affect insulin sensitivity and may represent a link between obesity, insulin resistance and type 2 diabetes (DM). The objective of this study was to compare the levels of resistin and adiponectin in type 2 diabetic obese female patients with and without hypertension and retinopathy. Subjects and Methods: In this study the plasma adiponectin and resistin concentrations were investigated, in 20 control obese non-diabetic females and 40 obese female patients with type 2 diabetes mellitus. The diabetic females were divided into 2 groups. GI included 20 controlled uncomplicated diabetics & GII included 20 diabetic patients with hypertension and retinopathy. Results: The plasma concentration of adiponectin was significantly lower (P< 0.01) in diabetic females in GΙ & GΠ than non-diabetic control females. In diabetic patients with hypertension and retinopathy ( GII) there was a significant decrease in plasma adiponectin levels (P< 0.01) as compared to their levels in diabetic females in GΙ and control females. Our results also show that there were non-significant changes in plasma resistin in diabetic patients in both groups GΙ & GII as compared to their levels in control group. Conclusion: These results suggest that adiponectin may play a key role in pathophysiology of type 2 diabetes mellitus and its microangiopathy and macrovascular complications. Key words: diabetes mellitus . obesity Introduction  

DOI

10.21608/ejhm.2006.17914

Authors

First Name

Seham M. S.

Last Name

EL – Nakeeb

MiddleName

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Affiliation

Biochemistry Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept

Email

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City

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Orcid

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First Name

Manal

Last Name

A.Lattif

MiddleName

-

Affiliation

Internal Medicine Dept Faculty of Medicine for Girls AL-Azhar University Clinical Pathology Dept

Email

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City

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Orcid

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First Name

Ahmed M

Last Name

.Ragheb

MiddleName

-

Affiliation

Faculty of Medicine AL-Azhar University, Faculty of Medical Technology

Email

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City

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Orcid

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First Name

Baker M.A.

Last Name

Albow

MiddleName

-

Affiliation

Mesalata- El- Margeb University

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City

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Orcid

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Volume

24

Article Issue

1

Related Issue

3737

Issue Date

2006-07-01

Receive Date

2018-10-30

Publish Date

2006-07-01

Page Start

515

Page End

523

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 24_Issue 1_Pages 515-523.pdf

PDF . 341.6kB

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https://ejhm.journals.ekb.eg/article_17914.html

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https://ejhm.journals.ekb.eg/service?article_code=17914

Order

9

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Plasma Adiponectin and Resistin Levels in Type 2 Diabetic Obese Female Patients With and Without Hypertension and Retinopathy

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Article

Created At

22 Jan 2023