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17910

Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis

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Last updated: 24 Dec 2024

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Abstract

Background : Psoriasis is a common inflammatory skin disorder, has received attention as a target for new pathogenesis and oriented therapies . Autoimmunity and T lymphocyte subsets are suggested to be involved in the development of psoriasis. The aim of this work is to asses the role of T lymphocyte subsets in the pathogenesis of psoriasis . Material And Methods :We investigated the peripheral blood lymphocyte subpopulations obtained from psoriatic patient before and after treatment and from healthy controls, using two colour flow cytometry. Results :We found highly significant suppression of total CD3+ T Cells and CD3+ CD56+ NKT lymphocytes in psoriatic patient as compared to control. Also, we observed significant reduction of T helper cells in patients as compared to control. Conclusion : The highly significant reduction of CD3+ T cell and CD3+ CD56+ NKT lymphocytes proved their actively involvement in the development of psoriasis.

DOI

10.21608/ejhm.2006.17910

Authors

First Name

Hanan M.A.

Last Name

Darwish

MiddleName

-

Affiliation

Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University

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Orcid

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First Name

Nahla M.

Last Name

Abd EL-Aziz

MiddleName

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Affiliation

Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University

Email

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City

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Orcid

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First Name

Fatma M.

Last Name

EL-Marzouky

MiddleName

-

Affiliation

Departments of Dermatology and Venereology & Clinical pathology Faculty of Medicine for Girls AL-AZhar University

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Volume

24

Article Issue

1

Related Issue

3737

Issue Date

2006-07-01

Receive Date

2018-10-30

Publish Date

2006-07-01

Page Start

477

Page End

483

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 24_Issue 1_Pages 477-483.pdf

PDF . 699.7kB

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https://ejhm.journals.ekb.eg/article_17910.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17910

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Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Flow Cytometric Analysis of Peripheral T lymphocyte Subpopulations in Psoriasis

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Article

Created At

22 Jan 2023