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Cd 34 Glycoprotein as A Differentiating Marker Between Basal Cell Carcinoma and Trichoepithelioma

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Last updated: 03 Jan 2025

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Abstract

Trichoepithelioma (TE) is a benign skin tumor with follicular differentiation, which is sometimes difficult to distinguish clinically and histologically from basal cell carcinoma (BCC). One of the most helpful differences is the histologic appearance of the stroma. CD34 is an antigen known to stain the spindle shaped cells located around the middle portion of normal hair follicles. We selected twenty clinically confused cases. After routine histopathological staining by haematoxylin and eosin, all cases showed typical diagnosis in seventeen cases (9BCC& 8TE) while the remaining three cases revealed overlapped features. Immunoperoxidase technique using anti-CD34 antibody carried out in all cases displayed two out of the three overlapped cases had a staining pattern similar to the typical BCC cases; the immediate tumor stroma together with the spindle cells intermixing the tumor nests were CD34 negative. Moreover, the remaining uncertainly diagnosed case had a pattern resembling the typical TE cases; the immediate tumor stroma as well as the spindle cells surrounding the tumor islands were focally CD34 positive. From our study, we concluded that the CD34 staining pattern can be considered as a helpful tool in differentiation between TE and BCC particularly when these lesians are in doubt about the clinical or routine histologic diagnosis.

DOI

10.21608/ejhm.2006.17810

Keywords

Key words: CD34 antigen-Immunohistochemistry

Authors

First Name

Amr M.

Last Name

Zaky

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Affiliation

Department of Dermatology, Venereology & Andrology Al-Azhar University (Cairo)

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First Name

Ahmed H.

Last Name

Abdel-Rahman

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Affiliation

Department of Pathology Al-Azhar university (Assuit)

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Volume

25

Article Issue

1

Related Issue

3736

Issue Date

2006-10-01

Receive Date

2018-10-29

Publish Date

2006-10-01

Page Start

703

Page End

710

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 25_Issue 1_Pages 703-710.pdf

PDF . 369.8kB

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https://ejhm.journals.ekb.eg/article_17810.html

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https://ejhm.journals.ekb.eg/service?article_code=17810

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Cd 34 Glycoprotein as A Differentiating Marker Between Basal Cell Carcinoma and Trichoepithelioma

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Article

Created At

22 Jan 2023