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17807

Sodium Barbital Induced Biochemical, Histological and Histochemical Changes in the Liver of Albino Mouse

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Last updated: 03 Jan 2025

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Abstract

Introduction:The present work was planned to assess and evaluate some physiological parameters, histopathological and histochemical impacts of sodium barbital on the liver of adult male albino mice.
Material and Methods :The mice were divided into 3 groups, the first group served as a control group, while the other two groups were treated with the therapeutic dose (60 mg/kg b.wt., i.p.) for 7 days (short-term group) and 21 days (long-term group) as repeated daily doses.
Results: Biochemical analysis showed a significant increase in serum glucose level (hyperglycaemia), AST, ALT and bilirubin, in all treated groups. Also, total lipids and triglycerides showed a significant increase in the long-term group and non significant change in the short-term group. On the other hand, alkaline phosphatase ALP, showed a significant decrease in both treated groups. Total cholesterol level showed a significant decrease in the short-term group but exhibited a significant increase in the long-term group. The results obtained from the present study showed marked alterations in the liver tissue. Histopathological changes in liver tissue were congestion of the central veins, wedening of the blood sinusoids, activation of the phagocytic küpffer cells and cytoplasmic degeneration (fatty and hydropic) with nuclear lesions. Histochemical changes in liver tissue revealed depletion of polysaccharides and total proteins in both short-term and long-term groups.
ConclusionSotheseresultscametoconclusionthat barbituratesshouldbeprohibitedand carefully used specially when prescribed as tranquilizer.
 

DOI

10.21608/ejhm.2006.17807

Keywords

Barbital, serum, Liver functions, histopathology, histochemistry

Authors

First Name

Shadia Ali

Last Name

Radwan

MiddleName

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Affiliation

Department of Biological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt.

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First Name

Aziza M.

Last Name

El-Wessemy

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-

Affiliation

Department of Biological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt.

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Orcid

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First Name

Samia M.

Last Name

Sakr

MiddleName

-

Affiliation

Department of Biological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt.

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Orcid

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First Name

Samira E.

Last Name

El-Harras

MiddleName

-

Affiliation

High Institution of Applied arts, 6th October City

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Volume

25

Article Issue

1

Related Issue

3736

Issue Date

2006-10-01

Receive Date

2018-10-29

Publish Date

2006-10-01

Page Start

656

Page End

671

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 25_Issue 1_Pages 656-671.pdf

PDF . 1.5MB

Link

https://ejhm.journals.ekb.eg/article_17807.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17807

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Sodium Barbital Induced Biochemical, Histological and Histochemical Changes in the Liver of Albino Mouse

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Article

Created At

22 Jan 2023