Background: aortic valve disease is common and its prevalence increases with age. For people over the age of 75 years, the prevalence of aortic stenosis (AS) is 5%. More than one in eight people over the age of 75 have moderate or severe valve disease. Aim of the Work: the aim of this study was to compare the short term results of aortic valve replacement through upper mini sternotomy and full sternotomy. Patients and Methods: This study was a prospective randomized controlled clinical trial. The study was conducted at Suez Canal University Hospital in the cardiothoracic operating rooms and inward after approval of Research and Ethics Committees. The study included 50 patients having aortic valve disease presented to Suez Canal University Hospital, cardiothoracic outpatient clinic for isolated aortic valve replacement. Results: The mean age of patients in Full Sternotomy in Aortic Valve Replacement (FSAVR) group was 33.48 ± 17.74 while it was 32.03 ± 15.29 in Mini Sternotomy in Aortic Valve Replacement (MSAVR) group which showed insignificance difference (p > 0.05). (20- 29y) was the most frequent age group in both study groups (28% in FSAVR group and 32% in MSAVR group). No significance different found (p > 0.05) according to gender in both group. Male gender was the most frequent in both group (56% in FSAVR group and 64% in MSAVR group). Conclusion: Mini Sternotomy (MS) can be considered as excellent option with favorable outcomes that should be considered part of the routine practice of cardiac surgeons in the modern era