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18261

Relation of neutrophil-to-lymphocyte, platelet-to-lymphocyte ratio and CRP level with coronary artery disease severity in patients undergoing coronary angiography

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Last updated: 24 Dec 2024

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Abstract

Background: coronary artery disease (CAD) is the leading cause of morbidity and mortality throughout the world. It has a complex pathophysiology, and inflammation seems to play an important role in CAD. Previous studies have shown that higher levels of inflammatory markers are associated with the severity of CAD and worse cardiovascular outcome. Although endothelial damage has been known as the triggering factor for the formation of atherosclerotic plagues, inflammatory process is responsible in the initiation and progression of the atherosclerosis. The neutrophil-to-lymphocyte ratio (NLR) and platelet- to-lymphocyte ratio (PLR) have recently been investigated as new predictors for worse cardiovascular outcome. Previous studies have shown that NLR is associated with morbidity and mortality in many cardiovascular diseases such as hypertension, heart failure, infective endocarditis, and acute coronary syndromes (ACS). Aims: The aim of this study was to explore the relation of NLR , PLR and CRP level with severity of coronary artery disease (CAD) using the Syntax score (Sxscore).
Patients and Methods: This study was conducted to investigate the relationship between the severity of coronary artery disease and inflammatory markers (lymphocyte ratio, lymphocyte platelet, CRP) by sytax score in patients undergoing elective coronary angiography, the active number of 100 patients with a chronic stable was taken Coronary angiography, different markers for coronary assessment, renal function tests, INR, ECG and Echocardiography. A complete clinical evaluation was performed for each of our patients Results: Coronary lesions were evaluated by the result of camel synthesis and there was a strong relationship between NLR, PLR, CRP level, and coronary heart disease r. 526 p 0.001, r 0.317 p 0.001, r 0.699 p 0.001 However, when we divided the patient for a result Syntax The results show some difference in determining who are drafting the sentence above 21, we found a negative relationship between NLR, PLR and syntax points, while the CRP level was positively correlated at the level of the structure below 31 a significant negative correlation was found with the construct conclusion above 31. Conclusion: Our study concluded that the severity of coronary artery disease is associated with NLR, PLR, CRP levels to some extent in the patient with angina for chronic stable chest.  

DOI

10.21608/ejhm.2018.18261

Keywords

Keywords: CAD, NLR, PLR, CRP, SYNTAX score

Authors

First Name

Mamdouh Helmy

Last Name

Al Tahhan

MiddleName

-

Affiliation

Department of Cardiology and Clinical Pathology, Faculty of Medicine, Al-Azhar University

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Orcid

-

First Name

Wael Refaat

Last Name

Hablas

MiddleName

-

Affiliation

Department of Cardiology and Clinical Pathology, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Abdul Mohsen

Last Name

Mostafa

MiddleName

-

Affiliation

Department of Cardiology and Clinical Pathology, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Sarhan

MiddleName

-

Affiliation

Department of Cardiology and Clinical Pathology, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Mostafa

Last Name

Mostafa

MiddleName

Adel

Affiliation

Department of Cardiology and Clinical Pathology, Faculty of Medicine, Al-Azhar University

Email

dr_mostafa_khamis@yahoo.com

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-

Orcid

-

Volume

73

Article Issue

8

Related Issue

3731

Issue Date

2018-10-01

Receive Date

2018-11-02

Publish Date

2018-10-01

Page Start

7,237

Page End

7,243

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 8_Pages 7237-7243.pdf

PDF . 542.2kB

Link

https://ejhm.journals.ekb.eg/article_18261.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18261

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6

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Relation of neutrophil-to-lymphocyte, platelet-to-lymphocyte ratio and CRP level with coronary artery disease severity in patients undergoing coronary angiography

Details

Type

Article

Created At

22 Jan 2023