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17795

Evaluation of Oral Anti-HCV Therapy (OAT) Effects on Serum Lipids Profile in Diabetic Patients

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Last updated: 24 Dec 2024

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Abstract

to down regulation of cholesterol level. Interferon (INF) therapy has been shown to decrease cholesterol even further during treatment .With the availability of direct acting antiviral agents (DAAs) the effect of suppressing HCV on lipid metabolism warrantes re-evaluation. Aim of the work : goal of our study was evaluation the changes in lipid profile after treatment of chronic HCV infection with oral antiviral medications in diabetic patients. Methods: this prospective study conducted on 90 HCV infected patients, all patients received Sofosbuvir (SOF) & Daclatasvir (DCV) as a dual therapy for 3 months. They were divided according to the presence or absence of diabetes mellitus (DM) and hyperlipidemia into three main groups; Group I: included 30 diabetic hyperlipidemic patients, Group II: included 30 non-diabetic hyperlipidemic patients, Group III: included 30 non-diabetic non- dyslipidemia patients.Changes of lipid profile on treatment with DAAs were assessed by checking fasting lipid profile at base line, then at end of treatment, and finally 3 months after treatment. Results: there was a statistically significant increase in total cholesterol level (TCHOL) which was maintained after the end of therapy. Changes in TCHOL were driven by changes in low-density lipo-protein (LDL) cholesterol, whereas high-density lipo-protien (HDL) cholesterol and very low-density lipo-protein (VLDL) cholesterol showed no significant changes. There were also no significant changes in tryglyceride (TG) level on treatment. Conclusion: eliminating HCV with DAAs increased TCHOL but had no effect on TG level.  

DOI

10.21608/ejhm.2018.17795

Keywords

Hepatitis C virus, Direct- acting antivirals

Authors

First Name

Abdou Mabrouk

Last Name

Al-Shafey

MiddleName

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Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

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Orcid

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First Name

Diaa Mohammad

Last Name

Eltebi

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

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City

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Orcid

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First Name

Islam Abdel-Mawla

Last Name

Ammar

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

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City

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Orcid

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First Name

Mohamad Ali

Last Name

Alnadar

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Email

mohamedali1990529@gmail.com

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Orcid

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Volume

73

Article Issue

8

Related Issue

3731

Issue Date

2018-10-01

Receive Date

2018-10-28

Publish Date

2018-10-01

Page Start

7,231

Page End

7,236

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 8_Pages 7231-7236.pdf

PDF . 400.3kB

Link

https://ejhm.journals.ekb.eg/article_17795.html

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https://ejhm.journals.ekb.eg/service?article_code=17795

Order

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of Oral Anti-HCV Therapy (OAT) Effects on Serum Lipids Profile in Diabetic Patients

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Article

Created At

22 Jan 2023