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17787

Relationship between Type 2 Diabetes Mellitus and the occurrence of Gastroesophageal varices in patients with chronic Hepatitis C Virus Related Liver Cirrhosis

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Last updated: 24 Dec 2024

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Abstract

Background: Hepatitis C virus (HCV) infection is a challenging health problem in Egypt. Esophageal varices are a major complication of it which may bleed and endanger patient's life.
Aim of the work: to assess the relationship between type-2 DM and the development of gastroesophageal varices and explore the role of insulin resistance as a predictor of gastroesophageal varices.
Patients and methods: This study included 100 patients with Child A, HCV-induced cirrhosis. They were divided into two main groups: Group A included 50 patients with type-2 DM, while Group B: included 50 non-diabetic which were subdivided into: Group B1: patients without DM but, with insulin resistance (IR) {32}, and Group B2: patients without DM or IR {18}. All patients were subjected to full history taking, clinical examination, laboratory and imaging studies (abdominal ultrasound) and upper GI endoscopy.
Results: The prevalence of esophageal varices in patients with Child A HCV-induced cirrhosis was 80%, elevated to 88% in patients with type-2 DM. Insulin resistance played the major role in development of esophageal varices. There are statistically significant elevated HOMA-IR score, lower platelet count/spleen diameter ratio and higher right liver lobe diameter/albumin ratio in patients with varices.
Conclusion: Insulin resistance is a major contributor for development of esophageal varices in HCV induced cirrhosis. Platelet count/spleen diameter ratio, right liver lobe diameter/albumin ratio and insulin resistance measured by HOMA-IR are good predictors for the presence of esophageal varices.

DOI

10.21608/ejhm.2018.17787

Keywords

Type-2 diabetes mellitus, Insulin Resistance, hepatitis C virus infection, gastroesophageal varices

Authors

First Name

Fathy G.

Last Name

Abdel-Raziq

MiddleName

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Affiliation

Internal Medicine Department, Faculty of Medicine, Al-Azhar University (Damietta)

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Orcid

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First Name

Mahmoud S.

Last Name

Berengy

MiddleName

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Affiliation

Internal Medicine Department, Faculty of Medicine, Al-Azhar University (Damietta)

Email

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City

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Orcid

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First Name

Ahmed RA

Last Name

Mohammed

MiddleName

-

Affiliation

Internal Medicine Department, Faculty of Medicine, Al-Azhar University (Damietta)

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City

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Orcid

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First Name

Tarek M.

Last Name

Emran

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Al-Azhar University (Damietta)

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Volume

73

Article Issue

8

Related Issue

3731

Issue Date

2018-10-01

Receive Date

2018-10-28

Publish Date

2018-10-01

Page Start

7,196

Page End

7,203

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 8_Pages 7196-7203.pdf

PDF . 387.4kB

Link

https://ejhm.journals.ekb.eg/article_17787.html

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https://ejhm.journals.ekb.eg/service?article_code=17787

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Relationship between Type 2 Diabetes Mellitus and the occurrence of Gastroesophageal varices in patients with chronic Hepatitis C Virus Related Liver Cirrhosis

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Article

Created At

22 Jan 2023