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17777

Effect of increase in Antioxidants Supplementation on Kidney Tissue of Mice Subjected to Fractionated Dose of γ-Irradiation.

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Last updated: 24 Dec 2024

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Abstract

Introduction: Although there is little doubt that antioxidants are a necessary component for good health, no one knows if supplements should be taken and, if so, how much. Materials and methods: To investigate the increase in antioxidants supplementation, a group of mice feeding on a diet containing 20% soybean was used as control group. The control group treated with 5% Nigella sativa and Antox drug (3 mg/mouse/day) either alone or in combination for 15 days. Another control group was treated with the same antioxidants and subjected to 1 Gy of γ- irradiation x 5 times day after day. In kidney tissue the levels of malonaldehyde (MDA) and reduced glutathione (GSH) were estimated. Also, the histopathological changes were recorded. Results: 5% Nigella sativa revealed a little decrease in MDA level and a highly significant decrease in GSH in kidney tissue while the exposure to fractionated dose of γ- irradiation predicted a highly significant decrease in MDA and a highly significant increase in GSH level. Gastric intubations of Antox drug showed a highly significant increase in MDA and GSH levels in kidney tissue either alone or in addition to fractionated radiation exposure. Combined treatments of Nigella sativa and Antox drug showed a highly significant decrease in MDA level and a highly significant increase in GSH level in kidney tissue in comparison to the control group. Histopathological changes showed that treatment with 5% Nigella sativa and Antox drug either alone or in combination revealed toxic effect on kidney tissue. However, their treatments prior to radiation exposure showed ameliorating effect. Conclusion: Our findings indicated that we under oxidative stress.

DOI

10.21608/ejhm.2007.17777

Authors

First Name

Hanafi

Last Name

N

MiddleName

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Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

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Orcid

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First Name

Abel Baset

Last Name

El Aaser

MiddleName

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Affiliation

cancer Biology Depart. Cancer Institute, Cairo University

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Orcid

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First Name

Mohamed S.

Last Name

Gabry

MiddleName

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Affiliation

Zoology Dept. Faculty of Science, Helwan University.

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City

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Orcid

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First Name

Amany A

Last Name

Tohamy

MiddleName

-

Affiliation

Zoology Dept. Faculty of Science, Helwan University.

Email

-

City

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Orcid

-

First Name

Manal El Saied

Last Name

Ebrahim

MiddleName

-

Affiliation

Zoology Dept. Faculty of Science, Helwan University.

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Volume

26

Article Issue

1

Related Issue

3715

Issue Date

2007-01-01

Receive Date

2018-10-28

Publish Date

2007-01-01

Page Start

22

Page End

30

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 26_Issue 1_Pages 22-30.pdf

PDF . 813.7kB

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https://ejhm.journals.ekb.eg/article_17777.html

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https://ejhm.journals.ekb.eg/service?article_code=17777

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of increase in Antioxidants Supplementation on Kidney Tissue of Mice Subjected to Fractionated Dose of γ-Irradiation.

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Article

Created At

22 Jan 2023