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Lipids and oxidative stress in blood serum of alloxan-induced diabetic rats: possible effects on liver and kidney tissues.

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Last updated: 24 Dec 2024

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Abstract

Experimental diabetes mellitus in rats was produced by a single dose of 200 mg of alloxan /kg body weight given intraperitoneally as an aqueous solution. The diabetic rats showed abnormal high blood glucose and variable increments in serum total lipids as well as in other serum lipid constituents particularly the triglycerides. Certain pathological abnormalities could be detected in both liver and kidney, particularly when the disturbances in glucose and lipid metabolism were more pronounced in a group of diabetic rats that received no insulin treatment {NIT} or after four weeks of the onset of diabetes. On the other hand, putting the group of diabetic rats on an insulin regimen from the start of the diabetic condition resulted in a significant restoration of most evaluated parameters to values almost similar to those of normal control animals. Diabetic rats receiving no insulin treatment showed a markedly significant loss in body weight; and started to gain body weight gradually when put on the proper insulin regimen.

DOI

10.21608/ejhm.2007.17726

Authors

First Name

Benrebai

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M

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Affiliation

Département des sciences de la nature et de la vie. Université Mentouri, Constantine 25000, Algeria.

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First Name

Abidli

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N

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Affiliation

Département des sciences de la nature et de la vie. Université Mentouri, Constantine 25000, Algeria.

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Orcid

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First Name

Benlatreche

Last Name

C

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Affiliation

Laboratoire de biochimie, CHU Benbadis, Constantine 25000, Algeria.

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Volume

27

Article Issue

1

Related Issue

3714

Issue Date

2007-04-01

Receive Date

2018-10-27

Publish Date

2007-04-01

Page Start

245

Page End

254

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 27_Issue 1_Pages 245-254.pdf

PDF . 571.9kB

Link

https://ejhm.journals.ekb.eg/article_17726.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=17726

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11

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Lipids and oxidative stress in blood serum of alloxan-induced diabetic rats: possible effects on liver and kidney tissues.

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Article

Created At

22 Jan 2023